Bosdou Julia K, Venetis Christos A, Anagnostis Panagiotis, Savvaidou Despoina, Chatzimeletiou Katerina, Zepiridis Leonidas, Goulis Dimitrios G, Grimbizis Grigoris, Kolibianakis Efstratios M
Unit for Human Reproduction, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.
Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece.
Int J Mol Sci. 2025 Feb 15;26(4):1656. doi: 10.3390/ijms26041656.
Studies in animals have shown that androgens promote early follicular development and granulosa cell proliferation by augmenting follicle-stimulating hormone (FSH) receptor expression in granulosa cells. Inconsistency exists regarding the association between basal serum androgen levels and follicular development in low responders undergoing in vitro fertilization (IVF), although the number of studies is limited. The aim of the current study was to assess the association between basal serum androgen concentrations and the number of follicles ≥ 11 mm on the day of triggering final oocyte maturation in low responders undergoing IVF. This prospective study was performed from June 2020 to September 2024 in 96 low responders, categorized according to the Bologna criteria. Total testosterone, dehydroepiandrosterone sulfate (DHEAS), 17-OH progesterone (17-OH-P), Δ-androstenedione (Δ4-A), and sex hormone-binding globulin (SHBG) were measured on the day of initiation of ovarian stimulation. No association was found between basal serum testosterone (coef.: -0.002, = 0.98), DHEAS (coef.: -0.096, = 0.35), 17-OH-P (coef.: +0.086, = 0.40), Δ-A (coef.: -0.028, = 0.79), and SHBG (coef.: +0.160, = 0.12) concentrations and the number of follicles ≥ 11 mm on the day of triggering final oocyte maturation. The results of the current study challenge the usefulness of basal serum androgen measurements prior to ovarian stimulation in low responders as predictors of ovarian response.
动物研究表明，雄激素可通过增加颗粒细胞中促卵泡激素（FSH）受体的表达来促进早期卵泡发育和颗粒细胞增殖。尽管相关研究数量有限，但关于接受体外受精（IVF）的低反应者基础血清雄激素水平与卵泡发育之间的关联仍存在不一致的情况。本研究的目的是评估接受IVF的低反应者在触发最终卵母细胞成熟当天基础血清雄激素浓度与≥11mm卵泡数量之间的关联。这项前瞻性研究于2020年6月至2024年9月对96名根据博洛尼亚标准分类的低反应者进行。在卵巢刺激开始当天测量总睾酮、硫酸脱氢表雄酮（DHEAS）、17-羟孕酮（17-OH-P）、Δ-雄烯二酮（Δ4-A）和性激素结合球蛋白（SHBG）。未发现基础血清睾酮（系数：-0.002，P = 0.98）、DHEAS（系数：-0.096，P = 0.35）、17-OH-P（系数：+0.086，P = 0.40）、Δ4-A（系数：-0.028，P = 0.79）和SHBG（系数：+0.160，P = 0.12）浓度与触发最终卵母细胞成熟当天≥11mm卵泡数量之间存在关联。本研究结果对在低反应者卵巢刺激前测量基础血清雄激素作为卵巢反应预测指标的实用性提出了质疑。
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