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Predictive Factors of Cardiac Function Recovery and Mortality in Patients with Reduced Ejection Fraction Undergoing Transcatheter Aortic Valve Implantation.

作者信息

Güney Murat Can, Süygün Hakan, Polat Melike, Ayhan Hüseyin, Keleş Telat, Turinay Ertop Zeynep Şeyma, Karasu Betül Banu, Bozkurt Engin

机构信息

Department of Cardiology, Faculty of Medicine, Medicana International Ankara Hospital, Atılım University, Söğütözü, 2176. Sk. No: 3, Çankaya 06510, Turkey.

Department of Cardiology, Faculty of Medicine, Karamanoglu Mehmetbey University, Karaman Training and Research Hospital, Karaman 70100, Turkey.

出版信息

Medicina (Kaunas). 2025 Feb 4;61(2):266. doi: 10.3390/medicina61020266.


DOI:10.3390/medicina61020266
PMID:40005384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11857224/
Abstract

: Patients with reduced left ventricular ejection fraction (LVEF) are reported to have unfavorable outcomes following transcatheter aortic valve implantation (TAVI). This study aims to evaluate outcomes and identify predictive factors for LVEF recovery following TAVI in patients with reduced LVEF. : This retrospective study analyzed 114 patients with symptomatic severe aortic stenosis (AS) with LVEF < 40% who underwent TAVI between 2011 and 2023 at two centers. Echocardiographic parameters, including LVEF, ventricular dimensions, and relative wall thickness (RWT), were assessed at baseline and during follow-up. The outcomes and predictors of substantial LVEF improvement and mortality were analyzed using univariate and multivariate logistic regression methods. : Anemia (OR = 4.345, 95% CI: 1.208-15.626, = 0.024), RWT (OR = 1.224, 95% CI: 1.064-1.407, = 0.005), and early post-procedural changes in left ventricular end-systolic dimension (LVESD) (OR = 1.297, 95% CI: 1.037-1.622, = 0.023) and left ventricular end-diastolic dimension (LVEDD) (OR = 1.346, 95% CI: 1.034-1.753, = 0.027) at one-month follow-up were identified as significant factors associated with LVEF recovery at one year. Regarding factors related to mortality, higher baseline AVMG levels were associated with a lower probability of death after one year (OR = 0.926, 95% CI: 0.875-0.979, = 0.007). Conversely, a more limited increase in LVEF from baseline to the final follow-up was linked to poor prognosis and higher mortality at one year (95% CI: 1.045-1.594, = 0.018). : This study demonstrated that TAVI in patients with AS and reduced LVEF can be performed with high procedural success, low mortality, and significant improvement in cardiac function during follow-up. Additionally, anemia, baseline RWT, and early post-procedural changes in LVESD and LVEDD were identified as factors associated with LVEF recovery. Baseline AVMG and changes in LVEF at the final follow-up were found to be significant predictors of total mortality.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a13d/11857224/3b0b6b4a185d/medicina-61-00266-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a13d/11857224/3b0b6b4a185d/medicina-61-00266-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a13d/11857224/3b0b6b4a185d/medicina-61-00266-g001.jpg

相似文献

[1]
Predictive Factors of Cardiac Function Recovery and Mortality in Patients with Reduced Ejection Fraction Undergoing Transcatheter Aortic Valve Implantation.

Medicina (Kaunas). 2025-2-4

[2]
Sustained favourable haemodynamics 1 year after TAVI: improvement in NYHA functional class related to improvement of left ventricular diastolic function.

Eur Heart J Cardiovasc Imaging. 2016-11

[3]
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[4]
Prognostic Significance of Change in the Left Ventricular Ejection Fraction After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis and Left Ventricular Dysfunction.

Am J Cardiol. 2017-11-1

[5]
Outcomes From Transcatheter Aortic Valve Replacement in Patients With Low-Flow, Low-Gradient Aortic Stenosis and Left Ventricular Ejection Fraction Less Than 30%: A Substudy From the TOPAS-TAVI Registry.

JAMA Cardiol. 2019-1-1

[6]
Impact of the recovery of left ventricular ejection fraction after TAVI on mortality in patients with aortic stenosis.

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[7]
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[8]
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[9]
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Clin Res Cardiol. 2024-3

[10]
Effect of Baseline Left Ventricular Ejection Fraction on 2-Year Outcomes After Transcatheter Aortic Valve Replacement: Analysis of the PARTNER 2 Trials.

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本文引用的文献

[1]
Prognostic Implications and Predictors of Mitral Regurgitancy Reduction After Transcatheter Aortic Valve Implantation.

Medicina (Kaunas). 2024-12-18

[2]
Outcomes and predictors of left ventricle recovery in patients with severe left ventricular dysfunction undergoing transcatheter aortic valve implantation.

EuroIntervention. 2024-4-15

[3]
Impact of the recovery of left ventricular ejection fraction after TAVI on mortality in patients with aortic stenosis.

Turk Kardiyol Dern Ars. 2021-12

[4]
Outcomes From Transcatheter Aortic Valve Replacement in Patients With Low-Flow, Low-Gradient Aortic Stenosis and Left Ventricular Ejection Fraction Less Than 30%: A Substudy From the TOPAS-TAVI Registry.

JAMA Cardiol. 2019-1-1

[5]
Impact of baseline left ventricular ejection fraction on outcome after transfemoral transcatheter aortic valve implantation in patients with and without low-gradient aortic stenosis.

Echocardiography. 2019-1

[6]
Transcatheter Aortic Valve Replacement in Patients With Low-Flow, Low-Gradient Aortic Stenosis: The TOPAS-TAVI Registry.

J Am Coll Cardiol. 2018-3-27

[7]
Prognostic significance of left ventricular concentric remodelling in patients with aortic stenosis.

Arch Cardiovasc Dis. 2017-1

[8]
Transcatheter aortic valve implantation in low ejection fraction/low transvalvular gradient patients: the rule of 40.

J Cardiovasc Med (Hagerstown). 2017-2

[9]
The impact of transcatheter aortic valve implantation on left ventricular performance and wall thickness - single-centre experience.

Postepy Kardiol Interwencyjnej. 2015

[10]
Effect on outcomes and exercise performance of anemia in patients with aortic stenosis who underwent transcatheter aortic valve replacement.

Am J Cardiol. 2015-2-15

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