Färdig Martin, Zaigham Suneela, Engström Gunnar, Janson Christer, Wollmer Per, Malinovschi Andrei
Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.
Department of Clinical Sciences, Cardiovascular Epidemiology, Lund University, Lund, Sweden.
ERJ Open Res. 2025 Feb 25;11(1). doi: 10.1183/23120541.00674-2024. eCollection 2025 Jan.
Low-grade systemic inflammation is linked to abnormal spirometry. Impulse oscillometry (IOS) is sensitive in detecting peripheral airway dysfunction, but inflammation in relation to IOS is poorly studied. The objectives of the present study were to analyse associations between C-reactive protein (CRP), blood eosinophils (B-Eos), blood neutrophils (B-Neu), blood lymphocytes (B-Lym), blood leukocytes (B-Leu), blood monocytes (B-Mono) and IOS.
Blood biomarkers and IOS were assessed in 10 602 adults (aged 50-65 years) within the Swedish CardioPulmonary bioImage Study (SCAPIS). Upper tertiles for CRP (>1.80 mg·L), B-Eos (>0.20 10·L), B-Neu (>3.40 10·L), B-Lym (>2.00 10·L), B-Leu (>6.10 10·L) and B-Mono (>0.50 10·L) were analysed in relation to the following abnormal IOS indices: resistance at 5 Hz, resistance at 20 Hz, area of reactance, resonant frequency (>95th percentile) and reactance at 5 Hz (<5th percentile), based on healthy, never-smoking SCAPIS participants.
Abnormal IOS was observed in 1715 (16.2%), of which 580 (33.8%) also had abnormal spirometry. Having several blood biomarkers in the upper tertile (1, 2-3 or 4-6 0) was overall associated with abnormal IOS; adjusted odds ratios (OR) and 95% confidence intervals (CI) ranging from 1.19 (1.02-1.38) to 2.27 (1.79-2.89). Furthermore, having 2-3 or more blood biomarkers 0 in the upper tertile was overall linked to abnormal IOS in participants with normal spirometry; adjusted OR (95% CI) ranging from 1.43 (1.17-1.75) to 1.75 (1.29-2.38).
Low-grade systemic inflammation was related to abnormal IOS and appeared consistent even when participants had normal spirometry.
低度全身炎症与肺功能测定异常有关。脉冲振荡法（IOS）在检测外周气道功能障碍方面很敏感，但与IOS相关的炎症研究较少。本研究的目的是分析C反应蛋白（CRP）、血液嗜酸性粒细胞（B-Eos）、血液中性粒细胞（B-Neu）、血液淋巴细胞（B-Lym）、血液白细胞（B-Leu）、血液单核细胞（B-Mono）与IOS之间的关联。
在瑞典心肺生物图像研究（SCAPIS）中，对10602名成年人（年龄50-65岁）进行了血液生物标志物和IOS评估。根据健康、从不吸烟的SCAPIS参与者，分析CRP（>1.80mg·L）、B-Eos（>0.20×10⁹·L）、B-Neu（>3.40×10⁹·L）、B-Lym（>2.00×10⁹·L）、B-Leu（>6.10×10⁹·L）和B-Mono（>0.50×10⁹·L）的上三分位数与以下异常IOS指标的关系：5Hz时的阻力、20Hz时的阻力、电抗面积、共振频率（>第95百分位数）和5Hz时的电抗（<第5百分位数）。
1715名（16.2%）参与者出现异常IOS，其中580名（33.8%）同时肺功能测定异常。多个血液生物标志物处于上三分位数（1个、2-3个或4-6个>0）总体上与异常IOS相关；调整后的优势比（OR）和95%置信区间（CI）为1.19（1.02-1.38）至2.27（1.79-2.89）。此外，在肺功能测定正常的参与者中，2-3个或更多血液生物标志物>0处于上三分位数总体上与异常IOS相关；调整后的OR（95%CI）为1.43（1.17-1.75）至1.75（1.29-2.38）。
低度全身炎症与异常IOS有关，即使参与者肺功能测定正常，这种关系似乎也一致。
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