重组DNA：挖掘未开发的微生物潜力，推动作物农业创新。

Recombinant DNA: unlocking untapped microbial potential for innovation in crop agriculture.

作者信息

Thakor Aranksha, Charles Trevor C

机构信息

University of Waterloo, Waterloo, Ontario, Canada.

University of Waterloo, Waterloo, Ontario, Canada; Metagenom Bio Life Science Inc., Waterloo, Ontario, Canada.

出版信息

Trends Biotechnol. 2025 Mar;43(3):533-539. doi: 10.1016/j.tibtech.2025.01.001.

DOI:10.1016/j.tibtech.2025.01.001

PMID:40015250

Abstract

The Asilomar Conference on Recombinant DNA, held in 1975, established guidelines for recombinant DNA (rDNA) research and laid the foundation for biotechnology regulations. While rDNA has driven significant advancements in pharmaceutical and crop biotechnology, the commercialization of plant-beneficial microbials developed using rDNA has lagged behind. This disparity may be attributed to a cumbersome regulatory framework shaped by the perception that rDNA products pose biosafety risks. To unlock the full potential of rDNA technology in addressing global challenges, regulatory reform for rDNA-derived microbial products for crop plants that reduce reliance on chemical fertilizers and pesticides is essential. Streamlining these barriers will enable greater societal benefits from microbial solutions in agriculture and beyond.

摘要

1975年举行的阿西洛马重组DNA会议确立了重组DNA（rDNA）研究的指导方针，并为生物技术监管奠定了基础。虽然rDNA推动了制药和作物生物技术的重大进展，但利用rDNA开发的对植物有益的微生物的商业化却滞后了。这种差距可能归因于一个繁琐的监管框架，该框架是由认为rDNA产品存在生物安全风险的观念形成的。为了释放rDNA技术在应对全球挑战方面的全部潜力，对用于作物的rDNA衍生微生物产品进行监管改革至关重要，这些产品可减少对化肥和农药的依赖。简化这些障碍将使农业及其他领域的微生物解决方案为社会带来更大的益处。