Mitsuhashi T, Chanoki Y, Kuwahara H, Sakai T, Masuda H, Sugino S
Tohoku J Exp Med. 1985 Mar;145(3):341-51. doi: 10.1620/tjem.145.341.
An animal model for the emphysematous bullae in the rabbit lung induced by methylcholanthrene and carrageenan was reported. In early stages (by 2 months) the cystic lesions associated with extensive pneumonia. In later stages the inflammation subsided and only the cystic lesions remained, resulting in typical, large emphysematous bullae.