Nidey Nichole, Raff Erica, Ferdous Khan Md Tareq, Watkins Shannon Lea, McAllister Jennifer M Jm, Kair Laura, Terplan Mishka, Greiner Andrea
From the Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA (NN); Division of Maternal Fetal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA (ER); Department of Public Health Sciences, Clemson University, Clemson, SC (MTFK); Department of Community and Behavioral Health, College of Public Health, University of Iowa, Iowa City, IA (SLW); Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH (JMM); Well Newborn Care, UC Davis Children's Hospital, Davis, CA (LK); Friends Research Institute, Baltimore, MD (MT); and University of Iowa Hospitals and Clinics, Iowa City, IA (AG).
J Addict Med. 2025 Mar 3. doi: 10.1097/ADM.0000000000001454.
Cannabis is 1 of the most commonly used substances during pregnancy, and there is mixed evidence of its impact on maternal outcomes, such as hypertensive disorders. Prior research on cannabis use during pregnancy has not accounted for use frequency, which might explain mixed results across studies. The objective of this study was to examine how frequencies of use during pregnancy are associated with hypertensive disorders.
This was a retrospective cohort study of the 2017-2018 Pregnancy Risk Assessment Monitoring System survey (n = 10,911/weighted n = 587,486). Frequency of cannabis use was categorized for analysis as follows: no use, minimal use (1 time per month or less), moderate use (2 times per month to 1 day per week), and frequent use (2-6 times per week to daily). Multivariable logistic regression models were used to examine how the frequency of cannabis use influenced the odds of experiencing hypertensive disorders during pregnancy.
Cannabis use, measured as a binary exposure variable (yes/no), was not associated with higher odds of hypertension during pregnancy (odds ratio, 0.86; 95% confidence interval, 0.54, 1.35). However, among those with any cannabis use, frequent use (vs minimal use) was associated with higher odds of hypertensive disorders (odds ratio, 3.44; confidence interval, 1.40, 8.43).
Identifying cannabis use frequency during pregnancy can help identify maternal risk of hypertensive disorders.
大麻是孕期最常用的物质之一，其对孕产妇结局（如高血压疾病）的影响证据不一。先前关于孕期使用大麻的研究未考虑使用频率，这可能解释了各研究结果的差异。本研究的目的是探讨孕期使用大麻的频率与高血压疾病之间的关联。
这是一项对2017 - 2018年妊娠风险评估监测系统调查（n = 10,911/加权n = 587,486）的回顾性队列研究。大麻使用频率分类如下进行分析：未使用、少量使用（每月1次或更少）、中度使用（每月2次至每周1天）和频繁使用（每周2 - 6次至每天）。多变量逻辑回归模型用于研究大麻使用频率如何影响孕期患高血压疾病的几率。
以二元暴露变量（是/否）衡量的大麻使用与孕期患高血压的较高几率无关（优势比，0.86；95%置信区间，0.54，1.35）。然而，在任何使用过大麻的人群中，频繁使用（与少量使用相比）与患高血压疾病的较高几率相关（优势比，3.44；置信区间，1.40，8.43）。
确定孕期大麻使用频率有助于识别孕产妇患高血压疾病的风险。
