一项音乐训练计划在促进小儿脑肿瘤幸存者神经可塑性方面的可行性、可接受性及潜在疗效：一项队列研究。
The feasibility, acceptability, and potential efficacy of a musical training program in promoting neuroplasticity among survivors of pediatric brain tumors: A cohort study.
作者信息
Chung Joyce Oi Kwan, Li William Ho Cheung, Leung Yin-Ping Doris, Cheung Theodore Ching Kong, Chiu Sau Ying, Pong Monique Sin Yu, Chan Godfrey Chi Fung
机构信息
The School of Nursing, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region.
The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region.
出版信息
Eur J Oncol Nurs. 2025 Jun;76:102851. doi: 10.1016/j.ejon.2025.102851. Epub 2025 Feb 28.
PURPOSE
Neurocognitive sequelae of cancer and its treatment are common among survivors of pediatric brain tumors. While musical training is a potential avenue for enhancing psychological outcomes and quality of life, its efficacy in promoting neuroplasticity among these survivors remains uncertain. We examined the feasibility, acceptability, and potential efficacy of implementing a musical training program for survivors of pediatric brain tumors.
METHODS
A cohort study was conducted on 40 survivors of pediatric brain tumors aged 7-16 years, who received 45 min of one-on-one music training per week for 52 weeks. Primary outcomes included eligibility rate, recruitment rate, retention rate, and process evaluation outcome. Secondary outcomes were nonverbal intelligence, attention, processing speed, and executive functions at baseline and after 12 months, measured by the Test of Nonverbal Intelligence (Fourth Edition), Digit Span, and the Children's Color Trails Test.
RESULTS
The eligibility rate (82.3%), recruitment rate (78.4%), and retention rate (82.5%) were high. Process evaluation showed the intervention was feasible and acceptable. Significant improvements were observed in attention (t = -9.11; 95% CI, -2.86 to -1.81; P < .001) and processing speed and executive functions (t = 5.56; 95% CI, 2.34 to 5.05; P < .001) but not nonverbal intelligence (t = -1.96; 95% CI, -3.01 to 0.05; P = .060) between baseline and 12-month follow-up.
CONCLUSIONS
This study demonstrated the feasibility, acceptability, and potential efficacy of implementing a musical training program among survivors of pediatric brain tumors. Our program may promote neuroplasticity, improve attention and executive function, and enhance quality of life and mental health. A fully powered randomized controlled trial is needed.
TRIAL REGISTRATION CLINICALTRIALS GOV IDENTIFIER
NCT05202925.
目的
癌症及其治疗的神经认知后遗症在小儿脑肿瘤幸存者中很常见。虽然音乐训练是改善心理状况和生活质量的一个潜在途径，但其在促进这些幸存者神经可塑性方面的功效仍不确定。我们研究了为小儿脑肿瘤幸存者实施音乐训练项目的可行性、可接受性和潜在功效。
方法
对40名7至16岁的小儿脑肿瘤幸存者进行了一项队列研究，他们每周接受45分钟的一对一音乐训练，为期52周。主要结局包括符合条件率、招募率、保留率和过程评估结果。次要结局是在基线时和12个月后通过非言语智力测验（第四版）、数字广度测验和儿童彩色轨迹测验测量的非言语智力、注意力、处理速度和执行功能。
结果
符合条件率（82.3%）、招募率（78.4%）和保留率（82.5%）都很高。过程评估表明该干预措施是可行且可接受的。在基线和12个月随访之间，注意力（t = -9.11；95% CI，-2.86至-1.81；P <.001）以及处理速度和执行功能（t = 5.56；95% CI，2.34至5.05；P <.001）有显著改善，但非言语智力没有（t = -1.96；95% CI，-3.01至0.05；P =.060）。
结论
本研究证明了在小儿脑肿瘤幸存者中实施音乐训练项目的可行性、可接受性和潜在功效。我们的项目可能促进神经可塑性，改善注意力和执行功能，并提高生活质量和心理健康水平。需要进行一项充分有力的随机对照试验。
试验注册 临床试验注册号：NCT05202925
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