Reddy Aswanth, Sekar Arjun, Nwankwo Nkolika, Kumar Aswini
Department of Hematology and Oncology Mercy Clinic, Fort Smith, AR, USA.
Department of Nephrology Rochester Regional Health, Rochester, NY, USA.
Brown J Hosp Med. 2022 Nov 1;1(4):39749. doi: 10.56305/001c.39749. eCollection 2022.
Allopurinol, utilized in the treatment of gouty arthritis and hyperuricemia, is one of the most prescribed medications in general medical practice. Although well-tolerated, allopurinol can cause rare and severe adverse reactions, including bone marrow toxicity. A 68-year-old man presented to the hospital with severe neutropenia and aseptic meningitis. After an extensive workup, allopurinol was determined to be the culprit medication causing severe agranulocytosis, and his blood counts recovered upon discontinuing the drug. Drug-induced agranulocytosis is a rare but serious adverse reaction. Treatment includes supportive care and discontinuation of the offending agent.
别嘌醇用于治疗痛风性关节炎和高尿酸血症，是普通医疗实践中最常处方的药物之一。尽管耐受性良好，但别嘌醇可引起罕见且严重的不良反应，包括骨髓毒性。一名68岁男性因严重中性粒细胞减少和无菌性脑膜炎入院。经过全面检查，确定别嘌醇是导致严重粒细胞缺乏症的罪魁祸首药物，停用该药物后他的血细胞计数恢复正常。药物性粒细胞缺乏症是一种罕见但严重的不良反应。治疗包括支持治疗和停用致病药物。
