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经皮颈总动脉穿刺置入支架治疗新生儿及婴儿动脉导管依赖性肺血流的动脉导管未闭:拉脱维亚的经验

Patent Ductus Arteriosus Stenting via Percutaneous Common Carotid Artery Access for Ductus Dependent Pulmonary Blood Flow in Newborns and Infants: Experience in Latvia.

作者信息

Grīnberga Zanda, Zaharāne Elizabete, Sīlis Pauls, Ozoliņš Valts, Sikora Normunds, Ligere Elīna

机构信息

Faculty of Residency, Riga Stradins University, Latvia.

Children's Clinical University Hospital, Department of Paediatric Cardiology and Cardiac Surgery, Riga, Latvia.

出版信息

Acta Med Litu. 2024;31(2):264-274. doi: 10.15388/Amed.2024.31.2.5. Epub 2024 Dec 4.

Abstract

BACKGROUND

Newborn patients with cyanotic congenital heart diseases with ductus-dependent pulmonary blood flow require neonatal repair, or palliation with a secure source of pulmonary blood flow, up to definitive surgical correction or palliation of the malformation. There is growing experience of percutaneous patent ductus arteriosus stenting to maintain the ductal flow. Patients in need of PDA stenting are newborns or small infants and recent data suggests that a weight of <4 kg increases the risk of thrombosis from femoral arterial catheterisation. Carotid access for newborn cardiac catheterisation avoids femoral arterial injury and improves the catheter course for certain transvasal procedures.

THE AIM OF THIS STUDY

was to report the Riga Children's Clinical University Hospital`s (CCUH) 7 year experience of patent ductus arteriosus stenting using the percutaneous transcarotidal approach in newborn babies and small infants with ductus-dependent critical heart diseases.

METHODS

A retrospective review of all newborn and small infants who underwent transcatheter arterial duct stenting through the percutaneous carotid artery approach at the CCUH in Riga, Latvia between the years 2013 and 2020.

RESULTS

In total, 8 patients underwent PDA stenting using the transcarotid approach between the years 2013 and 2020 in CCUH. The approach in all cases was chosen based on the anatomical features seen on echocardiography. In two cases, early restenting was necessary, while other patients had no procedure-associated complications. In the long term follow-up of 4 patients in two cases, dopplerography of the accessed common carotid artery showed stenotic changes up to 50%.

CONCLUSIONS

PDA stenting using the transcarotid approach is currently considered a relatively safe method and does not have a greater risk of developing postprocedural complications compared to the transfemoral approach. Transcarotidal PDA stenting in neonates and small infants with ductus-dependent critical congenital heart disease is possible in small volume paediatric cardiac surgery centre to stabilise the patient prior to definitive surgery or palliation of complex CHD. The vascular access should be chosen depending on the anatomical features of the patient and the competency of the cardiac interventionalist. From our experience, long-term changes in the affected common carotid artery may develop in a substantial number of cases, they may not be clinically significant in midterm follow-up period but have to be reevaluated. However, further randomised studies are necessary with large cohorts and longer follow-up period.

摘要

背景

患有依赖动脉导管的肺血流的青紫型先天性心脏病的新生儿患者需要进行新生儿修复,或通过安全的肺血流来源进行姑息治疗,直至对畸形进行确定性手术矫正或姑息治疗。经皮动脉导管未闭支架置入术以维持导管血流的经验越来越多。需要进行动脉导管未闭支架置入术的患者为新生儿或小婴儿,最近的数据表明,体重<4kg会增加股动脉插管血栓形成的风险。新生儿心脏导管插入术采用颈动脉入路可避免股动脉损伤,并改善某些经血管手术的导管路径。

本研究的目的

是报告里加儿童临床大学医院(CCUH)在7年中使用经皮经颈动脉入路对患有依赖动脉导管的严重心脏病的新生儿和小婴儿进行动脉导管未闭支架置入术的经验。

方法

回顾性分析2013年至2020年期间在拉脱维亚里加的CCUH通过经皮颈动脉入路接受经导管动脉导管支架置入术的所有新生儿和小婴儿。

结果

2013年至2020年期间,CCUH共有8例患者采用经颈动脉入路进行动脉导管未闭支架置入术。所有病例的入路均根据超声心动图显示的解剖特征选择。2例患者需要早期再次支架置入,而其他患者无手术相关并发症。在对2例患者中的4例进行长期随访时,对所使用的颈总动脉进行多普勒检查显示狭窄变化高达50%。

结论

目前认为,采用经颈动脉入路进行动脉导管未闭支架置入术是一种相对安全的方法,与经股动脉入路相比,术后并发症发生风险并不更高。在小规模儿科心脏手术中心,对患有依赖动脉导管的严重先天性心脏病的新生儿和小婴儿进行经颈动脉动脉导管未闭支架置入术,可在进行确定性手术或对复杂先天性心脏病进行姑息治疗之前使患者病情稳定。应根据患者的解剖特征和心脏介入医生的能力选择血管入路。根据我们的经验,相当一部分病例中受影响的颈总动脉可能会出现长期变化,在中期随访期间这些变化可能不具有临床意义,但必须重新评估。然而,需要进行进一步的大样本随机研究,并延长随访期。

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