Girndt J
Klin Wochenschr. 1979 Aug 1;57(15):793-5. doi: 10.1007/BF01478038.
Rats with experimental renovascular hypertension were treated with high doses of beta-blocking agents. Pindolol 10 mg/kg per day increased Goldblatt-type hypertension, whereas Propranolol 100 mg/kg per day showed an antihypertensive effect. A linear correlation between the weight of the left-heart ventricle and the systolic blood pressure was found in animals treated with Pindolol as well as in untreated Goldblatt rats. On the contrary, the weights of the left-heart ventricle were significantly higher in those animals treated with Propranolol than in the other groups. The results show that Pindolol in high doses, possibly on account of its sympathomimetic activity, leads to an increase in Goldblatt hypertension, but does not influence the pressure-dependent progression of left-heart hypertrophy. On the other hand, Propranolol, possibly on account of a cardiodepressory effect, leads to a decrease in blood pressure.
用高剂量的β受体阻滞剂治疗实验性肾血管性高血压大鼠。每天10毫克/千克的吲哚洛尔会使戈德布拉特型高血压加重，而每天100毫克/千克的普萘洛尔则显示出降压作用。在用吲哚洛尔治疗的动物以及未治疗的戈德布拉特大鼠中，发现左心室重量与收缩压之间存在线性相关性。相反，用普萘洛尔治疗的动物的左心室重量明显高于其他组。结果表明，高剂量的吲哚洛尔可能由于其拟交感神经活性导致戈德布拉特高血压加重，但不影响左心室肥厚的压力依赖性进展。另一方面，普萘洛尔可能由于其心脏抑制作用导致血压下降。
