Metastasis is the hallmark of malignancy but the spread to brain is an exceedingly rare occurrence for oral cancer. Two of our patients who underwent definitive surgery for oral cancer developed manifestations of Central nervous system (CNS) involvement within 7 days of surgery, one with seizures and other with cranial nerve palsies (3rd and 7th ), who were otherwise symptom free for CNS involvement preoperatively. These cases highlight the need for thorough metastasis workup including CNS.