Dehghani Sara, Rezvani Alireza, Shahriarirad Reza, Rajabian Mohammad Sadegh, Ziaian Bizhan, Fallahi Mohammad Javad, Mardani Parviz, Amirian Armin
Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Science, Shiraz, Iran.
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Cancer Rep (Hoboken). 2025 Mar;8(3):e70108. doi: 10.1002/cnr2.70108.
Globally, lung cancer is one of the most commonly diagnosed cancers and continues to take the lead in cancer-related mortality rates. This study aims to provide the latest statistics on the clinical, histopathological, and epidemiological features of lung cancer patients who underwent surgical resection in referral hospitals in Southern Iran.
In this retrospective study, records of all patients with operable primary and secondary lung cancer who underwent surgical resection of the lung in Shiraz hospitals, located in Southern Iran from November 2009 to May 2022 were screened. Data on demographic, clinical, surgical, and pathological characteristics were analyzed by SPSS software.
A total of 232 patients with operable lung cancer, including 150 (64.7%) primary cases and 82 (35.3%) secondary cases, underwent 249 operations. The mean age of primary and secondary lung cancer patients was 56.70 ± 13.99 and 45.56 ± 18.88, respectively (p < 0.001). Males accounted for 54.0% and 58.5% of primary and secondary lung cancer patients, respectively. Adenocarcinoma was the most frequent primary pathology, while sarcomas were the most common metastatic lesions. The predominant presenting symptoms were cough (n = 75, 75.0%) and dyspnea (n = 31, 59.7%) in primary and secondary cases, respectively. Involvement of the right lung was more frequent in both groups (65.5% and 53.1% for primary and secondary cases respectively). The most commonly performed surgeries were lobectomy (69.9%) and limited resection (69.8%) for primary and secondary lesions, respectively. Cigarette smoking and extensive resection had a significant association with the in-hospital mortality rate (p = 0.012 and 0.009 respectively). The overall in-hospital mortality rate was 3.6% (n = 9).
Surgical interventions were mostly performed in men and histopathologic subtypes of primary lung adenocarcinoma, metastatic soft tissue sarcoma, and metastatic colon cancer. Smoking and extensive resection accompany a higher risk of short-term postoperative mortality.
在全球范围内，肺癌是最常被诊断出的癌症之一，并且在癌症相关死亡率方面持续位居榜首。本研究旨在提供有关在伊朗南部转诊医院接受手术切除的肺癌患者的临床、组织病理学和流行病学特征的最新统计数据。
在这项回顾性研究中，筛选了2009年11月至2022年5月期间在位于伊朗南部的设拉子医院接受肺部手术切除的所有可手术的原发性和继发性肺癌患者的记录。通过SPSS软件分析人口统计学、临床、手术和病理特征数据。
共有232例可手术的肺癌患者接受了249次手术，其中包括150例（64.7%）原发性病例和82例（35.3%）继发性病例。原发性和继发性肺癌患者的平均年龄分别为56.70±13.99岁和45.56±18.88岁（p<0.001）。男性分别占原发性和继发性肺癌患者的54.0%和58.5%。腺癌是最常见的原发性病理类型，而肉瘤是最常见的转移病灶。原发性和继发性病例中主要的临床表现分别为咳嗽（n=75，75.0%）和呼吸困难（n=31，59.7%）。两组中右肺受累更为常见（原发性和继发性病例分别为65.5%和53.1%）。原发性和继发性病变最常进行的手术分别是肺叶切除术（69.9%）和局限性切除术（69.8%）。吸烟和广泛切除与住院死亡率显著相关（分别为p=0.012和0.009）。总体住院死亡率为3.6%（n=9）。
手术干预主要针对男性以及原发性肺腺癌、转移性软组织肉瘤和转移性结肠癌的组织病理学亚型。吸烟和广泛切除伴随着更高的术后短期死亡风险。
Zotero 插件
