海胆孢子素的抗肿瘤活性。

Antitumor activity of echinosporin.

作者信息

Morimoto M, Imai R

出版信息

J Antibiot (Tokyo). 1985 Apr;38(4):490-5. doi: 10.7164/antibiotics.38.490.

DOI:10.7164/antibiotics.38.490

Abstract

Echinosporin isolated from a Streptomyces culture showed antitumor activity against rodent tumor models such as leukemia P388, P388/VCR, and fibrosarcoma Meth 1. It was marginally active against melanoma B16 and sarcoma 180. It was not active against Lewis lung carcinoma and xenograft MX-1. It inhibited the colony formation of HeLa S3 cells with a wide shoulder at low dose ranges. DNA, RNA, and protein synthesis were inhibited by echinosporin. It depressed WBC with nadir on day 3, but the recovery to the normal level after echinosporin injection was more rapid than that after mitomycin C.

摘要

从链霉菌培养物中分离出的棘孢菌素对啮齿动物肿瘤模型，如白血病P388、P388/VCR和纤维肉瘤Meth 1，显示出抗肿瘤活性。它对黑色素瘤B16和肉瘤180的活性较弱。它对Lewis肺癌和异种移植MX-1无活性。在低剂量范围内，它以宽平台抑制HeLa S3细胞的集落形成。棘孢菌素抑制DNA、RNA和蛋白质合成。它在第3天使白细胞减少至最低点，但注射棘孢菌素后恢复到正常水平的速度比丝裂霉素C后更快。