(1) Breast cancer is one of the most common malignancies in women worldwide. Breast cancer-related lymphedema (BCRL) is a serious complication that develops as a result of damage or dysfunction of the normal functioning lymphatic system. This review aims to assess the effectiveness of Kinesio Taping in the treatment of BCRL based on randomized controlled trials. (2) This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Four electronic databases were searched: PubMed, Cochrane, PEDro, and Google Scholar. This study included female patients with any stage of lymphedema after mastectomy. There were no restrictions on age, race, or nationality. (3) The literature search yielded 608 results. Eight articles met all required eligibility criteria and were included in this study. A diverse range of physical therapy interventions were used, and efficacy was measured using a variety of outcomes and measures. The summarized results indicate that Kinesio Taping applications had a positive effect on a range of outcomes, including upper limb circumference, pain, ROM, and functional status. (4) Given the modest evidence supporting the use of Kinesio Taping for the treatment of BCRL, there is a need for further prospective studies.