Wei Min, Xia Dongyun, Takashi En, Qiu Yansen, Huang Li, Sun Zhen, Weng Yajuan
Wound Care Center, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Division of Basic & Clinical Medicine, Faculty of Nursing, Nagano College of Nursing, Nagano, Japan.
Int J Low Extrem Wounds. 2025 Sep;24(3):605-610. doi: 10.1177/15347346251326251. Epub 2025 Mar 17.
AimTo clarify the clinical characteristics of autoimmune disease (AID)-related ulcers to improve treatment outcomes.Materials and MethodsThe medical records of 189 patients treated for AID-related ulcers at two tertiary hospitals in Nanjing, China, from January 1, 2018 to December 31, 2022 were retrospectively reviewed. The relevant clinical data included diagnosis, type and severity of wounds, and prescribed medications.ResultsOf the 189 patients with AID-related ulcers, 146 (77.25%) were female and 43 (22.75%) were male. The top four immunological diagnoses were rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, and vasculitis. The four most common wound sites were the lower limb, foot, hand, and upper limb. Regarding the number of wounds, 81 (42.86%) patients had one ulcer, 43 (22.75%) had two, 30 (15.87%) had three, and 35 (18.52%) had four or more. More than half of the patients (54%, 102/189) were previously treated for AID-related ulcers. Of these 102 patients, 27 (26.47%) had one previous diagnosis, 49 (40.83%) had two, and 26 (25.49%) had three or more. Among all 189 patients, 142 (75%) had clinical symptoms of local infection. Of these 142 patients, bacteria cultures were conducted for 70 (49.30%), of which 63 (90.00%) were positive. The most commonly detected bacteria were , , , and . The median (interquartile range) duration of AID-related ulcers was 55 (39, 90) days. Most patients (87.3%, 165/189) received systemic therapy with immunosuppressants and hormones.ConclusionsThe most common clinical characteristics of AID-associated ulcers were spontaneous rupture, long duration, multiple wounds, bacterial infection, and recurrence. Clarification of the clinical characteristics of AID-associated ulcers can improve treatment outcomes.
阐明自身免疫性疾病（AID）相关溃疡的临床特征，以改善治疗效果。
回顾性分析2018年1月1日至2022年12月31日在中国南京两家三级医院接受治疗的189例AID相关溃疡患者的病历。相关临床数据包括诊断、伤口类型和严重程度以及所开药物。
在189例AID相关溃疡患者中，女性146例（77.25%），男性43例（22.75%）。前四位的免疫诊断为类风湿关节炎、系统性红斑狼疮、干燥综合征和血管炎。四个最常见的伤口部位是下肢、足部、手部和上肢。关于伤口数量，81例（42.86%）患者有1处溃疡，43例（22.75%）有2处，30例（15.87%）有3处，35例（18.52%）有4处或更多。超过一半的患者（54%，102/189）曾接受过AID相关溃疡的治疗。在这102例患者中，27例（26.47%）曾有过1次诊断，49例（40.83%）有过2次，26例（25.49%）有过3次或更多次。在所有189例患者中，142例（75%）有局部感染的临床症状。在这142例患者中，70例（49.30%）进行了细菌培养，其中63例（90.00%）呈阳性。最常检测到的细菌是 、 、 和 。AID相关溃疡的中位（四分位间距）持续时间为55（39，90）天。大多数患者（87.3%，165/189）接受了免疫抑制剂和激素的全身治疗。
AID相关溃疡最常见的临床特征是自发破裂、持续时间长、多处伤口、细菌感染和复发。阐明AID相关溃疡的临床特征可改善治疗效果。
