Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.
作者信息
Taylor E C, Harrington P J, Fletcher S R, Beardsley G P, Moran R G
出版信息
J Med Chem. 1985 Jul;28(7):914-21. doi: 10.1021/jm00145a012.
PMID:4009615
Abstract
Total syntheses from pyridine precursors of 5,10-dideazaaminopterin (1) and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin (2) are described. These compounds exhibit significant in vivo activity against L1210 leukemia that is comparable to that observed with methotrexate.
摘要
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