Abdelrahman Maha S I, Saleh Mohamed G A, Aly Maha Abdelgaber A, Salah Shaimaa
Department of Rheumatology, Rehabilitation and Physical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.
Department of Ophthalmology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Eur Arch Otorhinolaryngol. 2025 Mar 18. doi: 10.1007/s00405-025-09280-5.
We aimed to analyze auditory involvement in patients with Behcet's disease and its association with Optical Coherence Tomography Angiography findings and disease manifestations.
This study included 54 eyes and 68 ears of 34 adults with Behcet's disease in comparison to 30 eyes and 60 ears of healthy controls. Clinical, laboratory and ophthalmological evaluation including Optical Coherence Tomography Angiography was done. Audiological assessment included otoscopic examination, immitancemetry and pure tone and speech audiometry.
Sensorineural hearing loss was observed in 32.35% of the studied cases. Behcet's disease patients showed significantly higher average hearing level and significant reduction of retinal vessel density compared to controls. Patients with sensorineural hearing loss demonstrated significantly lower central retinal capillary vessel density and higher neuro-Behcet's disease incidence in comparison to those without hearing loss (p-value = 0.039 and 0.024, respectively), which was confirmed by univariate regression analysis. After entering significant factors into the multivariate model, neuro-BD was identified as the most significant single predictor of sensorineural hearing loss in BD (p-value = 0.003).
The association between sensorineural hearing loss and central retinal vessel density reduction and neuro- Behcet's disease should be considered in Behcet's disease.
我们旨在分析白塞病患者的听觉受累情况及其与光学相干断层扫描血管造影结果和疾病表现的关联。
本研究纳入了34名患有白塞病的成年人的54只眼和68只耳，并与30只眼和60只耳的健康对照进行比较。进行了包括光学相干断层扫描血管造影在内的临床、实验室和眼科评估。听力评估包括耳镜检查、声导抗测量以及纯音和言语听力测定。
在所研究的病例中，32.35%观察到感音神经性听力损失。与对照组相比，白塞病患者的平均听力水平显著更高，视网膜血管密度显著降低。与无听力损失的患者相比，感音神经性听力损失患者的视网膜中央毛细血管密度显著更低，神经白塞病发病率更高（p值分别为0.039和0.024），单因素回归分析证实了这一点。将显著因素纳入多变量模型后，神经白塞病被确定为白塞病中感音神经性听力损失的最显著单一预测因素（p值 = 0.003）。
在白塞病中应考虑感音神经性听力损失与视网膜中央血管密度降低和神经白塞病之间的关联。
