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一种用于皮肤保健的表皮丝氨酸传感系统。

An epidermal serine sensing system for skin healthcare.

作者信息

Yuan Ying, Zhong Bowen, Qin Xiaokun, Xu Hao, Li Zhexin, Li Linlin, Wang Xiaofeng, Zhang Wenxuan, Lou Zheng, Fan Yongming, Wang Lili

机构信息

State Key Laboratory of Semiconductor Physics and Chip Technologies, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China.

Center of Materials Science and Optoelectronic Engineering, University of Chinese Academy of Sciences, Beijing, China.

出版信息

Nat Commun. 2025 Mar 18;16(1):2681. doi: 10.1038/s41467-025-58147-0.

DOI:10.1038/s41467-025-58147-0
PMID:40102486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11920223/
Abstract

Portable biosensors mainly focus on detecting biomarkers in biofluids but neglect the abundant skin biomarkers on the stratum corneum, which are associated with the functionality and integrity of the skin barrier. Here, we propose a sensing patch designed for direct sampling and in situ quantification of epidermal serine, an important biomarker for skin healthcare. The patch consists of a porous hydrogel for serine diffusion and ion conduction, and a molecular imprinted polymer-based electrochemical serine sensor. By integrating with a customized handheld serine tester, the serine sensing system enables in situ measurement of epidermal serine levels. We demonstrate the application of this serine sensing system in assessing the moisturizing effect of a skincare product and tracking the recovery progress of skin barrier function in a patient with atopic dermatitis. Our work opens up a potential application scenario for portable biosensors in personalized skin healthcare.

摘要

便携式生物传感器主要专注于检测生物流体中的生物标志物，却忽略了角质层上丰富的皮肤生物标志物，而这些生物标志物与皮肤屏障的功能和完整性相关。在此，我们提出一种传感贴片，旨在直接采样并原位定量检测表皮丝氨酸，这是一种对皮肤健康至关重要的生物标志物。该贴片由用于丝氨酸扩散和离子传导的多孔水凝胶以及基于分子印迹聚合物的电化学丝氨酸传感器组成。通过与定制的手持式丝氨酸测试仪集成，丝氨酸传感系统能够原位测量表皮丝氨酸水平。我们展示了这种丝氨酸传感系统在评估护肤品保湿效果以及跟踪特应性皮炎患者皮肤屏障功能恢复进程中的应用。我们的工作为便携式生物传感器在个性化皮肤健康护理中开辟了一个潜在的应用场景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7041/11920223/6d9ff0e59787/41467_2025_58147_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7041/11920223/0355f039d031/41467_2025_58147_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7041/11920223/db5087bf6a5b/41467_2025_58147_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7041/11920223/17529894cb60/41467_2025_58147_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7041/11920223/6d9ff0e59787/41467_2025_58147_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7041/11920223/0355f039d031/41467_2025_58147_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7041/11920223/db5087bf6a5b/41467_2025_58147_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7041/11920223/17529894cb60/41467_2025_58147_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7041/11920223/6d9ff0e59787/41467_2025_58147_Fig4_HTML.jpg

相似文献

[1]
An epidermal serine sensing system for skin healthcare.

Nat Commun. 2025-3-18

[2]
Epidermal biomarkers of the skin barrier in atopic and contact dermatitis.

Contact Dermatitis. 2023-10

[3]
Stretchable ionic-electronic bilayer hydrogel electronics enable in situ detection of solid-state epidermal biomarkers.

Nat Mater. 2024-8

[4]
Transdermal Sensing of Enzyme Biomarker Enabled by Chemo-Responsive Probe-Modified Epidermal Microneedle Patch in Human Skin Tissue.

Adv Mater. 2024-7

[5]
Emerging innovations in portable chemical sensing devices: Advancements from microneedles to hydrogel, microfluidic, and paper-based platforms.

Talanta. 2024-10-1

[6]
iTRAQ-based quantitative proteomics of stratum corneum of dandruff scalp reveals new insights into its aetiology and similarities with atopic dermatitis.

Arch Dermatol Res. 2016-11

[7]
Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients.

Curr Probl Dermatol. 2016

[8]
Transepidermal water loss (TEWL) and corneometry with hydrogel vehicle in the treatment of atopic dermatitis: a randomized, investigator-blind pilot study.

J Drugs Dermatol. 2012-2

[9]
A study to assess the occlusivity and moisturization potential of three topical corticosteroid products using the skin trauma after razor shaving (STARS) bioassay.

J Drugs Dermatol. 2014-5

[10]
Influence of Topical Formulations: Lipid Lamella Organization and Lipid Composition of Stratum Corneum as a Surrogate Marker for Barrier Integrity.

Curr Probl Dermatol. 2018

引用本文的文献

[1]
Enhanced laser-induced PEDOT-based hydrogels for highly conductive bioelectronics.

Natl Sci Rev. 2025-4-4

本文引用的文献

[1]
Biomarkers in Cutaneous Keratinocyte Carcinomas.

Dermatol Ther (Heidelb). 2024-8

[2]
Multifunctional Dopamine-Based Hydrogel Microneedle Electrode for Continuous Ketone Sensing.

Adv Mater. 2024-8

[3]
Fully Integrated Multiplexed Wristwatch for Real-Time Monitoring of Electrolyte Ions in Sweat.

ACS Nano. 2024-5-21

[4]
Framework Nucleic Acids Combined with 3D Hybridization Chain Reaction Amplifiers for Monitoring Multiple Human Tear Cytokines.

Adv Mater. 2024-6

[5]
RNA-sequencing of paired tape-strips and skin biopsies in atopic dermatitis reveals key differences.

Allergy. 2024-6

[6]
A physicochemical-sensing electronic skin for stress response monitoring.

Nat Electron. 2024-2

[7]
The circadian metabolome of atopic dermatitis.

J Allergy Clin Immunol. 2024-4

[8]
A comprehensive review on signaling attributes of serine and serine metabolism in health and disease.

Int J Biol Macromol. 2024-3

[9]
Interindividual- and blood-correlated sweat phenylalanine multimodal analytical biochips for tracking exercise metabolism.

Nat Commun. 2024-1-20

[10]
The challenges and promise of sweat sensing.

Nat Biotechnol. 2024-6

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