Wang Yinglong, Feng Zuxi, Li Lijuan, Zhang Liansheng
Lanzhou University Second Hospital, Lanzhou, China.
Department of Hematology, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Front Immunol. 2025 Mar 4;16:1511616. doi: 10.3389/fimmu.2025.1511616. eCollection 2025.
MDS is a heterogeneous group of myeloid neoplasms originating from hematopoietic stem cells, with a high risk of transformation into acute myeloid leukemia (AML). Natural Killer (NK) cells, crucial for their role in immune surveillance and efficient tumor cell lysis, experience functional impairments due to the complex microenvironment and cytokine dynamics in MDS. This article focuses on the mechanisms of NK cell dysfunction in MDS and the latest strategies to enhance NK cell activity to restore their anti-MDS efficacy, highlighting their key role and potential in MDS therapy.
骨髓增生异常综合征（MDS）是一组起源于造血干细胞的异质性髓系肿瘤，具有转化为急性髓系白血病（AML）的高风险。自然杀伤（NK）细胞在免疫监视和有效裂解肿瘤细胞方面发挥着关键作用，但由于MDS中复杂的微环境和细胞因子动态变化，NK细胞会出现功能障碍。本文重点探讨MDS中NK细胞功能障碍的机制以及增强NK细胞活性以恢复其抗MDS疗效的最新策略，强调它们在MDS治疗中的关键作用和潜力。
