Fawad Aisha, Muzaffar Waqar, Anjum Unnab, Amer Mahad Naseer
Aisha Fawad, FCPS (Ophth), FRCSGlas (Ophth) Associate Professor of Ophthalmology, Refractive Department, National University of Medical Sciences, National University of Medical Sciences, Rawalpindi, Pakistan.
Waqar Muzaffar, FCPS (Ophth), FRCS (Edinburgh), CST (UK) Professor and Dean of Ophthalmology, National University of Medical Sciences, National University of Medical Sciences, Rawalpindi, Pakistan.
Pak J Med Sci. 2025 Mar;41(3):926-928. doi: 10.12669/pjms.41.3.11237.
Losartan, commonly used as an angiotensin receptor II inhibitor for hypertension, has recently revealed additional therapeutic properties. Studies demonstrate its potential in treating liver fibrosis, mitigating heart disease secondary to radiation, reducing skin scar formation, and even reversing renal cortical fibrosis. In a specific case, a female patient suffering from persistent bilateral nummular keratitis and corneal opacities experienced significant improvement in her left eye after using 0.8mg/ml Losartan eye drops. Untreated right eye showed no change. Based on the positive outcome, patient was offered same treatment in her right eye as well with monthly follow-ups, which she happily accepted. The stark contrast between the treated and untreated eye highlights the promising role of Losartan in treating corneal opacities.
氯沙坦通常用作治疗高血压的血管紧张素 II 受体抑制剂，最近还显示出其他治疗特性。研究表明其在治疗肝纤维化、减轻放疗引起的心脏病、减少皮肤瘢痕形成甚至逆转肾皮质纤维化方面具有潜力。在一个具体病例中，一名患有持续性双侧钱币状角膜炎和角膜混浊的女性患者，使用 0.8mg/ml 氯沙坦眼药水后左眼有显著改善。未经治疗的右眼没有变化。基于这一积极结果，也为该患者右眼提供了同样的治疗并每月进行随访，她欣然接受。治疗眼和未治疗眼之间的鲜明对比凸显了氯沙坦在治疗角膜混浊方面的前景。
