用于治疗慢性疲劳的具有螺[[1,3]恶唑并[5,4 - ]喹唑啉 - 9,1'-环己烷] - 7 - 酮骨架的磷酸二酯酶 - 7抑制剂的鉴定
Identification of Phosphodiesterase-7 Inhibitors with Spiro[[1,3]oxazolo[5,4-]quinazoline-9,1'-cyclohexan]-7-one Scaffold for the Treatment of Chronic Fatigue.
作者信息
Song Zhendong, Liang Steven H
机构信息
Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
出版信息
ACS Med Chem Lett. 2025 Mar 13;16(3):356-357. doi: 10.1021/acsmedchemlett.5c00001.
Abstract
The invention in this patent relates to the use of phosphodiesterase-7 (PDE7) inhibitors with a spiro[[1,3]oxazolo[5,4-]quinazoline-9,1'-cyclohexan]-7-one scaffold for the treatment and prevention of diseases and syndromes associated with chronic fatigue, exhaustion, and exertional intolerance.
摘要
本专利中的发明涉及一种具有螺[[1,3]恶唑并[5,4-]喹唑啉-9,1'-环己烷]-7-酮骨架的磷酸二酯酶-7（PDE7）抑制剂，用于治疗和预防与慢性疲劳、疲惫及运动不耐受相关的疾病和综合征。
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