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Biomechanical Evaluation of Cervical Interbody Fusion Cages for Anterior Cervical Discectomy and Fusion With Variations in Morphology: A Finite Element Analysis.

作者信息

Manickam Pechimuthu Susai, Dhason Raja, Bock Ryan, Bal Sonny, Roy Sandipan, Datta Shubhabrata

机构信息

Centre for Biomechanics, Department of Mechanical Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.

Centre for Composites and Advanced Materials, Department of Mechanical Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.

出版信息

Biomed Eng Comput Biol. 2025 Mar 17;16:11795972251321307. doi: 10.1177/11795972251321307. eCollection 2025.


DOI:10.1177/11795972251321307
PMID:40104840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11915299/
Abstract

The spinal diseases commonly faced by people in the 19th century included intervertebral disc degeneration, tuberculosis and congenital defects that resulted in neurological impairment and global disability. To address these issues, cervical spine surgery was performed. Modern techniques currently used in spine surgery include interbody devices, pedicle screws, artificial discs and bone grafts. The postoperative complications clinically reported during follow-up include nonunion and implant subsidence, which remain significant drawbacks. The objective of this study is to develop a 3-dimensional finite element model of the C2-C7 cervical spine and validate it against existing experimental studies. The loading conditions considered for this study include a compressive preload of 50 N and a 1 Nm moment applied to the C2 vertebra, with the C7 vertebra fixed at the bottom. In this study, the biomechanical alterations of 4 different cage morphologies were analysed using finite element analysis. Valeo cages with 4 distinct designs were implanted at the C5-C6 level, and physiological motion at the surgical site was studied. Cage subsidence and migration, which can lead to adjacent segment disc degeneration, were also examined. Subsidence was primarily attributed to higher stress encountered in the cage, so stress distribution within the cages was evaluated. Additionally, stress distribution in the anterior plate and screws was analysed. The study concludes that introducing anterior plate and screw fixation helps prevent cage subsidence. Physiological motion at the surgical level was reduced compared to the intact model. Adjacent disc stress was also evaluated and found to be lower than in the intact model.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/3b0f8ce7120a/10.1177_11795972251321307-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/2aaddde4b28b/10.1177_11795972251321307-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/664f72406f53/10.1177_11795972251321307-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/764d92b5b7d3/10.1177_11795972251321307-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/a71784443e01/10.1177_11795972251321307-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/3f5a6eb8d5f7/10.1177_11795972251321307-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/db1d9f9cd107/10.1177_11795972251321307-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/a193b43802ac/10.1177_11795972251321307-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/5781d7addfb9/10.1177_11795972251321307-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/9627c3be2bcb/10.1177_11795972251321307-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/3b0f8ce7120a/10.1177_11795972251321307-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/2aaddde4b28b/10.1177_11795972251321307-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/664f72406f53/10.1177_11795972251321307-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/764d92b5b7d3/10.1177_11795972251321307-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/a71784443e01/10.1177_11795972251321307-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/3f5a6eb8d5f7/10.1177_11795972251321307-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/db1d9f9cd107/10.1177_11795972251321307-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/a193b43802ac/10.1177_11795972251321307-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/5781d7addfb9/10.1177_11795972251321307-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/9627c3be2bcb/10.1177_11795972251321307-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91e/11915299/3b0f8ce7120a/10.1177_11795972251321307-fig10.jpg

相似文献

[1]
Biomechanical Evaluation of Cervical Interbody Fusion Cages for Anterior Cervical Discectomy and Fusion With Variations in Morphology: A Finite Element Analysis.

Biomed Eng Comput Biol. 2025-3-17

[2]
Biomechanical effect of different plate-to-disc distance on surgical and adjacent segment in anterior cervical discectomy and fusion - a finite element analysis.

BMC Musculoskelet Disord. 2021-4-9

[3]
A Dynamic Interbody Cage Improves Bone Formation in Anterior Cervical Surgery: A Porcine Biomechanical Study.

Clin Orthop Relat Res. 2021-11-1

[4]
Cage-screw and anterior plating combination reduces the risk of micromotion and subsidence in multilevel anterior cervical discectomy and fusion-a finite element study.

Spine J. 2021-5

[5]
Can an Endplate-conformed Cervical Cage Provide a Better Biomechanical Environment than a Typical Non-conformed Cage?: A Finite Element Model and Cadaver Study.

Orthop Surg. 2016-8

[6]
Biomechanical evaluation of a novel individualized zero-profile cage for anterior cervical discectomy and fusion: a finite element analysis.

Front Bioeng Biotechnol. 2023-9-7

[7]
Biomechanical analysis of a single-level customized cage screw fixation for anterior cervical discectomy and fusion in the cervical spine: anstudy.

Biomed Phys Eng Express. 2023-5-30

[8]
Adjacent segment biomechanical changes after one- or two-level anterior cervical discectomy and fusion using either a zero-profile device or cage plus plate: A finite element analysis.

Comput Biol Med. 2020-5

[9]
Factors affecting sagittal malalignment due to cage subsidence in standalone cage assisted anterior cervical fusion.

Eur Spine J. 2007-9

[10]
Biomechanical Evaluation of Intervertebral Fusion Process After Anterior Cervical Discectomy and Fusion: A Finite Element Study.

Front Bioeng Biotechnol. 2022-3-17

本文引用的文献

[1]
Finite Element Analysis Comparing the Biomechanical Parameters in Multilevel Posterior Cervical Instrumentation Model Involving Lateral Mass Screw versus Transpedicular Screw Fixation at the C7 Vertebra.

Asian Spine J. 2024-4

[2]
Biomechanical analysis of the novel S-type dynamic cage by implementation of teaching learning based optimization algorithm - An experimental and finite element study.

Med Eng Phys. 2023-2

[3]
Comparative Analysis of Cage Subsidence in Anterior Cervical Decompression and Fusion: Zero Profile Anchored Spacer (ROI-C) vs. Conventional Cage and Plate Construct.

Front Surg. 2021-10-27

[4]
The biomechanical effects of S-type dynamic cage using Ti and PEEK for ACDF surgery on cervical spine varying loads.

Int J Artif Organs. 2021-10

[5]
Expectoration of anterior cervical discectomy and fusion cage: a case report.

J Spine Surg. 2021-6

[6]
Biomechanical Evaluation of a Novel S-Type, Dynamic Zero-Profile Cage Design for Anterior Cervical Discectomy and Fusion with Variations in Bone Graft Shape: A Finite Element Analysis.

World Neurosurg. 2021-10

[7]
The biomechanical study of cervical spine: A Finite Element Analysis.

Int J Artif Organs. 2022-1

[8]
Analysis of the Variables Affecting the Incidence, Location, and Severity of Cage Subsidence Following Anterior Cervical Discectomy and Fusion Operation.

Int J Spine Surg. 2020-12

[9]
In Situ Spectroscopic Screening of Osteosarcoma Living Cells on Stoichiometry-Modulated Silicon Nitride Bioceramic Surfaces.

ACS Biomater Sci Eng. 2016-7-11

[10]
Radiographic cervical spine degenerative findings: a study on a large population from age 18 to 97 years.

Eur Spine J. 2021-2

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