二恶英的肝毒性剂量不会损伤小鼠骨髓染色体。

Hepatotoxic doses of dioxin do not damage mouse bone marrow chromosomes.

作者信息

Meyne J, Allison D C, Bose K, Jordan S W, Ridolpho P F, Smith J

出版信息

Mutat Res. 1985 Jul;157(1):63-9. doi: 10.1016/0165-1218(85)90050-3.

Abstract

We report on a study of the cytogenetic and hepatotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mice of the C57B1/6J (with high-affinity TCDD receptor) or DBA/2J (with low-affinity TCDD receptor) strains were given single intraperitoneal injections of 50, 100 or 150 micrograms of TCDD/kg body weight. At various times (8-48 h) after injection, we examined bone marrow cells for cytogenetic effects by performing structural aberration, sister-chromatid exchange, and micronucleus tests. 1 month after exposure, liver sections were studied for hepatotoxic effects. We found no evidence of chromosome damage by TCDD given in doses that cause liver damage in both strains of mice.

摘要

我们报告了一项关于2,3,7,8-四氯二苯并对二恶英（TCDD）的细胞遗传学和肝毒性作用的研究。给C57B1/6J（具有高亲和力TCDD受体）或DBA/2J（具有低亲和力TCDD受体）品系的小鼠腹腔内单次注射50、100或150微克TCDD/千克体重。在注射后的不同时间（8 - 48小时），我们通过进行结构畸变、姐妹染色单体交换和微核试验来检查骨髓细胞的细胞遗传学效应。暴露1个月后，研究肝脏切片的肝毒性作用。我们发现，在两种品系的小鼠中，能导致肝损伤的剂量的TCDD并未造成染色体损伤。