Davies Andrew, Zamora-Talaya Bernarda, Sabharwal Sanjeeve, Liddle Alexander D, Vella-Baldacchino Martinique, Rangan Amar, Reilly Peter
Bioengineering, Imperial College London, London, UK
NIHR London IVD Cooperative, Imperial College London, London, UK.
BMJ Open. 2025 Mar 18;15(3):e086150. doi: 10.1136/bmjopen-2024-086150.
The aim of this study was to compare the cost-effectiveness of total shoulder arthroplasty (TSA) and hemiarthroplasty (HA) and explore variation by age and gender.
Cost-effectiveness analysis using a lifetime cohort Markov model.
National population registry data.
Model parameters were informed by propensity score-matched comparisons of TSA and HA in patients with osteoarthritis and an intact rotator cuff using data from the National Joint Registry.
TSA and HA.
Quality-adjusted life years (QALYs) and healthcare costs for age and gender subgroups. A probabilistic sensitivity analysis was performed.
In all subgroups, TSA was more cost-effective, with the probability of being cost-effective about 70% for TSA versus 30% for HA at any willingness-to-pay threshold above £1100 per QALY. TSA was dominant in young patients (60 years) with a mean cost saving of £463 in men and £658 in women, and a mean QALY gain of 2 in both men and women. In patients aged 61-75 years, there was a mean cost saving following HA of £395 in men and £181 in women, while QALYs remained superior following TSA with a 1.3 gain in men and 1.4 in women. In the older cohort (> 75 years), the cost difference was highest and the QALY difference was lowest; there was a cost-saving following HA of £905 in men and £966 in women. The mean QALY gain remained larger after TSA: 0.7 in men and 0.9 in women.
TSA was more cost-effective than HA in patients with osteoarthritis. QALYs were superior following TSA in all patient groups. Cost differences varied by age and TSA was dominant in young patients.
本研究旨在比较全肩关节置换术(TSA)和半肩关节置换术(HA)的成本效益,并探讨年龄和性别的差异。
使用终生队列马尔可夫模型进行成本效益分析。
国家人口登记数据。
模型参数来自于使用国家关节登记处数据对骨关节炎且肩袖完整患者进行的TSA和HA倾向评分匹配比较。
TSA和HA。
年龄和性别亚组的质量调整生命年(QALYs)和医疗保健成本。进行了概率敏感性分析。
在所有亚组中,TSA更具成本效益,在任何每QALY支付意愿阈值高于1100英镑时,TSA具有成本效益的概率约为70%,而HA为30%。TSA在年轻患者(60岁)中占主导地位,男性平均节省成本463英镑,女性节省658英镑,男性和女性的平均QALY均增加2。在61 - 75岁的患者中,HA术后男性平均节省成本395英镑,女性节省181英镑,而TSA术后QALYs仍然更优,男性增加1.3,女性增加1.4。在老年队列(>75岁)中,成本差异最大,QALY差异最小;HA术后男性节省成本905英镑,女性节省966英镑。TSA术后平均QALY增加仍然更大:男性为0.7,女性为0.9。
在骨关节炎患者中,TSA比HA更具成本效益。在所有患者组中,TSA术后的QALYs更优。成本差异因年龄而异,TSA在年轻患者中占主导地位。