1型糖尿病中调节性T细胞的失调与治疗前景
Dysregulation and therapeutic prospects of regulatory T cells in type 1 diabetes.
作者信息
Syed Khaja Azharuddin Sajid, Binsaleh Naif K, Qanash Husam, Alshetaiwi Hamad, Ginawi Ibrahim Abdelmageed Mohamed, Saleem Mohd
机构信息
Department of Pathology, College of Medicine, University of Hail, 55476, Hail, Saudi Arabia.
Medical and Diagnostic Research Centre, University of Hail, 55476, Hail, Saudi Arabia.
出版信息
Acta Diabetol. 2025 Mar 21. doi: 10.1007/s00592-025-02478-3.
Type 1 diabetes (T1D) is an autoimmune disease that selectively destroys β-cells in the pancreas that produce insulin. Several studies have implicated and elaborated the significant role of regulatory T cells (Tregs) in the pathogenesis of T1D. Tregs are a specialized subset of T cells and are critical regulators of peripheral self-tolerance. However, if the number, function, or stability of these cells is altered, it can lead to autoimmunity. This review summarizes the current knowledge and understanding about Treg function in both health and T1D, Tregs dysregulation, and various factors, including microRNAs, that affect their dysregulation in T1D. The review also focuses on the advantages and challenges of Treg-based therapies for T1D.
1型糖尿病（T1D）是一种自身免疫性疾病，它会选择性地破坏胰腺中产生胰岛素的β细胞。多项研究已经表明并阐述了调节性T细胞（Tregs）在T1D发病机制中的重要作用。Tregs是T细胞的一个特殊亚群，是外周自身耐受性的关键调节因子。然而，如果这些细胞的数量、功能或稳定性发生改变，就可能导致自身免疫。这篇综述总结了目前关于Tregs在健康和T1D中的功能、Tregs失调以及包括微小RNA在内的各种影响其在T1D中失调的因素的知识和理解。该综述还重点介绍了基于Tregs的T1D治疗方法的优势和挑战。
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