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一名3个月大索马里女婴表现为脑膜炎症状的罕见Dandy-Walker综合征:病例报告

A Rare Presentation of Dandy-Walker Syndrome with Meningitis Symptoms in a 3-Month-Old Female: A Case Study From Somalia.

作者信息

Ali Abdirahman Omer, Abdilahi Salah Abdikarim, Ahmed Hinda Abdiwahab, Ahmed Hodan Hassan, Muse Abdirasak Abdulkadir, Abdi Mohamoud Hashi

机构信息

College of Health Sciences, Department of Medicine and Surgery, Amoud University, Borama, Somalia.

Borama Regional Hospital, Pediatric Department, Borama, Somalia.

出版信息

Pediatric Health Med Ther. 2025 Mar 20;16:75-81. doi: 10.2147/PHMT.S501020. eCollection 2025.

Abstract

Dandy-Walker Syndrome (DWS) is a rare cerebellar malformation characterized by the underdevelopment of the cerebellar vermis and associated complications. This case report presents a 3-month-old female from Somalia who exhibited fever, loss of consciousness, vomiting, and developmental delays. Neurological examination suggested signs of meningitis, and MRI revealed an enlarged posterior fossa consistent with DWS. Despite initial antibiotic treatment for suspected bacterial meningitis, CSF cultures yielded no growth, raising concerns about prior antibiotic use. Unfortunately, the patient's condition deteriorated, leading to her death. This case highlights the diagnostic challenges of DWS in resource-limited settings and emphasizes the need for improved healthcare access, early diagnosis, and intervention for rare neurological conditions.

摘要

丹迪-沃克综合征(DWS)是一种罕见的小脑畸形,其特征为小脑蚓部发育不全及相关并发症。本病例报告介绍了一名来自索马里的3个月大女性,她出现发热、意识丧失、呕吐和发育迟缓。神经系统检查提示有脑膜炎体征,磁共振成像(MRI)显示后颅窝增大,符合丹迪-沃克综合征。尽管最初针对疑似细菌性脑膜炎进行了抗生素治疗,但脑脊液培养无细菌生长,这引发了对先前使用抗生素的担忧。不幸的是,患者病情恶化,最终死亡。本病例突出了在资源有限环境中丹迪-沃克综合征的诊断挑战,并强调了改善医疗服务可及性、早期诊断以及对罕见神经系统疾病进行干预的必要性。

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