皮质醇和心理压力水平会影响转移性黑色素瘤患者免疫治疗的效果吗？一项初步研究。
Do cortisol and psychological distress levels impact the effectiveness of immunotherapy in patients with metastasized melanoma? A pilot study.
作者信息
Hinnen Chris, Tijssens Frederiek, von Haeseler Emma, van de Berg Sjoerd, Kapiteijn Ellen
机构信息
Psycho-oncology, Leiden University Medical Centre, Leiden.
Department of Psychiatry and Medical Psychology, Spaarne Gasthuis, Haarlem.
出版信息
Melanoma Res. 2025 Jun 1;35(3):204-207. doi: 10.1097/CMR.0000000000001035. Epub 2025 Mar 25.
This pilot study investigates the relationship between endogenous cortisol and subjective distress and immunotherapy response in patients with advanced melanoma. Patients were asked to donate hair and complete questionnaires. This data was related to immunotherapy response, 3 and 6 months after start. Results from 21 patients were analyzed and showed that there was a significant relationship between depressive symptoms before start of immunotherapy and response 3 and 6 months after start of immunotherapy. Also, a higher baseline level of glucocorticoids was found to be significantly associated with a higher response rate 6 months after start of immunotherapy. The present pilot study warrants further investigation into the relationship between stress and the effectiveness of immunotherapy in patients with advanced melanoma.
这项初步研究调查了晚期黑色素瘤患者内源性皮质醇与主观痛苦及免疫治疗反应之间的关系。研究要求患者捐献头发并完成问卷调查。这些数据与免疫治疗开始后3个月和6个月的反应相关。对21名患者的结果进行了分析，结果显示免疫治疗开始前的抑郁症状与免疫治疗开始后3个月和6个月的反应之间存在显著关系。此外，还发现糖皮质激素的基线水平较高与免疫治疗开始后6个月的较高反应率显著相关。目前的初步研究值得进一步探讨压力与晚期黑色素瘤患者免疫治疗效果之间的关系。
Zotero 插件