Chen Ning, Pei Xiaohui, Sun Hao, Zhang Yaoyun, Wang Mengmeng, Song Ziqian, Wang Jialin, Qi Yuantao
Binhai County People's Hospital, Yancheng, 224500, Jiangsu, China.
The Second Affiliated Hospital, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China.
Eur J Med Res. 2025 Mar 26;30(1):209. doi: 10.1186/s40001-025-02472-z.
The objective of this study was to investigate the relationship between the age of menarche and the prevalence of malignancies of the uterus and ovaries.
A total of 5540 women were screened from those who participated in the National Health And Nutrition Examination Survey (NHANES) questionnaire from 2007 to 2020, and their variable factors of age, race, education level, Poverty Impact Ratio (PIR), marital status, Body Mass Index (BMI), waist circumference, duration of moderate exercise, smoking habits, hypertension status, energy intake, diabetes and alcohol consumption habits were analysed statistically and by logistic regression.
Univariate and multivariate logistic regression analysis of the relationship between age at menarche and gynaecological cancer (uterus/cervix/ovary cancer, the following gynecologic cancers in the article refer to having at least one of these three cancers) prevalence showed a negative association between age at menarche and malignancies of the uterus and ovaries prevalence (OR: 0.82, 95% CI 0.69-0.97), with a statistically significant difference (p = 0.02). Regression results of the association between age at menarche and different types of malignancies of the uterus and ovaries found a negative association between age at menarche and prevalence in uterine cancers (P = 0.03) and no association between age at menarche and prevalence in cervical and ovarian cancers (P = 0.17, P = 0.29). Those with a younger age at menarche were more likely to develop uterine cancer (OR: 0.72, 95% CI 0.54-0.98).
There was a correlation between age at menarche and malignancies of the uterus and ovaries, with those who had menarche at an earlier age being at a higher risk of uterine cancer.
本研究的目的是调查初潮年龄与子宫和卵巢恶性肿瘤患病率之间的关系。
从2007年至2020年参加美国国家健康和营养检查调查（NHANES）问卷的人群中筛选出5540名女性，并对她们的年龄、种族、教育水平、贫困影响比率（PIR）、婚姻状况、体重指数（BMI）、腰围、适度运动时长、吸烟习惯、高血压状况、能量摄入、糖尿病和饮酒习惯等可变因素进行统计学分析和逻辑回归分析。
对初潮年龄与妇科癌症（子宫/宫颈癌/卵巢癌，本文以下的妇科癌症指至少患有这三种癌症中的一种）患病率之间的关系进行单因素和多因素逻辑回归分析，结果显示初潮年龄与子宫和卵巢恶性肿瘤患病率之间呈负相关（OR：0.82，95%可信区间0.69 - 0.97），差异有统计学意义（p = 0.02）。初潮年龄与子宫和卵巢不同类型恶性肿瘤之间关联的回归结果发现，初潮年龄与子宫癌患病率之间呈负相关（P = 0.03），而初潮年龄与宫颈癌和卵巢癌患病率之间无关联（P = 0.17，P = 0.29）。初潮年龄较小的女性患子宫癌的可能性更大（OR：0.72，95%可信区间0.54 - 0.98）。
初潮年龄与子宫和卵巢恶性肿瘤之间存在相关性，初潮年龄较早的女性患子宫癌的风险更高。
