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Rech. f. & Esfand as adjunctive therapy for eradication: a randomized controlled trial.

作者信息

Vaziri Nima, Dehghannoudeh Gholamreza, Sharififar Fariba, Dabaghzadeh Fatemeh, Sarafzadeh Farhad, Ahmadi Bizhan

机构信息

Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman 761, Iran.

Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman 761, Iran.

出版信息

J Tradit Chin Med. 2025 Apr;45(2):437-442. doi: 10.19852/j.cnki.jtcm.2025.02.009.


DOI:10.19852/j.cnki.jtcm.2025.02.009
PMID:40151130
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11955750/
Abstract

OBJECTIVE: To evaluate the effect of this plant as adjunctive therapy on () eradication. METHODS: The plant capsules were prepared and their physicochemical properties were assessed. In this clinical trial, 99 patients with infection were randomized to receive Rech. f. & Esfand () or placebo capsules for two weeks. All the patients in both groups received clarithromycin-based triple therapy. Both intention to treat and per protocol analyses were performed. Eradication rates, treatment side effects, and medication compliance were evaluated in both groups. RESULTS: H. pylori eradication rate of all the randomized participants was 59.59%. The eradication rate of was significantly higher in group compared with that in the placebo group for per protocol analysis (84.62%, = 0.026) but not for intention to treat one (65.31%, 0.252). There were no significant differences between the two groups regarding the frequencies of the medications side effects and the patients with poor compliance. CONCLUSION: The use of as adjunctive therapy to 14-day clarithromycin-based triple therapy might improve eradication rate.

摘要

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Rech. f. & Esfand as adjunctive therapy for eradication: a randomized controlled trial.

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本文引用的文献

[1]
Development and In Vitro Evaluation of Oral Capsules from : A Convenient Substitute for Peripheral Neuropathy.

Adv Pharmacol Pharm Sci. 2022-4-27

[2]
Phytochemical and biological activities of some Iranian medicinal plants.

Pharm Biol. 2022-12

[3]
Levofloxacin-based therapy as an efficient alternative for eradicating Helicobacter pylori infection in Iran: a systematic review and meta-analysis.

J Glob Antimicrob Resist. 2022-6

[4]
AGA Clinical Practice Update on the Management of Refractory Helicobacter pylori Infection: Expert Review.

Gastroenterology. 2021-4

[5]
Iranian Salvia species: A phytochemical and pharmacological update.

Phytochemistry. 2021-3

[6]
Plants against to combat resistance: An ethnopharmacological review.

Biotechnol Rep (Amst). 2020-5-21

[7]
An Updated Systematic Review and Meta-Analysis on the Antibiotic Resistance in Iran (2010-2020).

Microb Drug Resist. 2020-10

[8]
Intention to treat and per protocol analysis in clinical trials.

Nephrology (Carlton). 2020-7

[9]
Comparison between  daily single-dose triple therapy and conventional triple therapy on patient compliance and Helicobacter pylori eradication: A randomized controlled  trial.

Indian J Gastroenterol. 2018-11

[10]
Eradication of in Iran: A Review.

Middle East J Dig Dis. 2018-1

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