Gajewska Joanna, Rowicka Grażyna, Klemarczyk Witold, Głąb-Jabłońska Ewa, Ambroszkiewicz Jadwiga
Department of Screening Tests and Metabolic Diagnostics, Institute of Mother and Child, Warsaw 01-211, Kasprzaka 17a, Poland.
Outpatient Gastroenterology Clinic, Institute of Mother and Child, Warsaw 01-211, Kasprzaka 17a Poland.
J Mother Child. 2025 Mar 28;29(1):1-9. doi: 10.34763/jmotherandchild.20252901.d-24-00049. eCollection 2025 Mar 1.
Leptin physiology in children is crucial for diagnosing and managing pediatric endocrine and metabolic disorders. The aim of this study was to assess the values of leptin, leptin receptor (sOB-R), and free leptin index (FLI) depending on age and sex in healthy Polish children and adolescents.
A total of 236 children and adolescents aged 1-18 years were recruited. Leptin and leptin receptor concentrations were determined by immunoenzymatic methods. FLI values were calculated as leptin divided by sOB-R concentrations. In 114 children between the ages of 5 and 10 years, a measurement of fat mass was assessed by dual-energy X-ray absorptiometry.
The studied groups of girls and boys were of similar age and did not differ in terms of weight, height, body mass index (BMI), BMI Z-score values, or leptin receptor concentrations. Leptin concentrations and FLI were higher by about 50% (p=0.006; p=0.051, respectively) in girls than boys. Positive correlations were found between leptin and age, BMI, and BMI Z-score values (r=0.562, r=0.563, p=0.397; p<0.001, respectively), and even stronger between FLI and age, BMI, and BMI Z-score values (r=0.670, r=0.632, p=0.409; p<0.001, respectively).
The results concerning leptin and leptin receptor concentrations and FLI values in healthy individuals may be useful in clinical practice in early identification of children and adolescents with an unfavorable adipokine profile resulting in a predisposition to the development of obesity and obesity-related complications. These markers may also be helpful in monitoring therapy effectiveness in patients with obesity, diabetes, and metabolic syndrome.
儿童瘦素生理学对于诊断和管理儿科内分泌及代谢紊乱至关重要。本研究的目的是评估健康波兰儿童和青少年中瘦素、瘦素受体（sOB-R）和游离瘦素指数（FLI）随年龄和性别的变化情况。
共招募了236名1至18岁的儿童和青少年。采用免疫酶法测定瘦素和瘦素受体浓度。FLI值通过瘦素除以sOB-R浓度计算得出。对114名5至10岁的儿童，采用双能X线吸收法测量脂肪量。
所研究的女孩组和男孩组年龄相似，在体重、身高、体重指数（BMI）、BMI Z评分值或瘦素受体浓度方面无差异。女孩的瘦素浓度和FLI比男孩高约50%（分别为p = 0.006；p = 0.051）。瘦素与年龄、BMI和BMI Z评分值之间存在正相关（r = 0.562，r = 0.563，p = 0.397；p < 0.001），FLI与年龄、BMI和BMI Z评分值之间的相关性更强（r = 0.670，r = 0.632，p = 0.409；p < 0.001）。
关于健康个体中瘦素和瘦素受体浓度以及FLI值的研究结果，可能有助于临床实践中早期识别具有不良脂肪因子谱、易患肥胖症及肥胖相关并发症的儿童和青少年。这些标志物也可能有助于监测肥胖、糖尿病和代谢综合征患者的治疗效果。
