Yang Tzong-Hann, Cheng Yen-Fu, Lin Herng-Ching, Chen Chin-Shyan
Department of Otorhinolaryngology, Taipei City Hospital, Taipei, Taiwan.
Department of Speech, Language and Audiology, National Taipei University of Nursing and Health, Taipei, Taiwan.
J Periodontol. 2025 Mar 28. doi: 10.1002/JPER.24-0744.
Chronic rhinosinusitis (CRS) and chronic periodontitis (CP) are prevalent inflammatory conditions with significant impacts on health. Previous research has suggested a potential link between these diseases, primarily through odontogenic sources, but comprehensive population-based studies are scarce. This study aimed to explore the association of CRS with prior CP.
We performed a case-control study using Taiwan's Longitudinal Health Insurance Database, encompassing a group of 52,733 individuals diagnosed with CRS and 158,199 matched controls without CRS. The study identified patients with pre-existing CP using International Classification of Diseases codes, examining their prevalence before the index date of CRS diagnosis, comparing against matched controls without CRS. Multiple logistic regression models adjusted for demographic and health variables assessed the association between CRS and CP.
Our analysis indicated a significantly higher prevalence of CP among patients with CRS in comparison with controls (30.49% vs. 22.14%; p < 0.001). The adjusted odds ratio for having CP before the diagnosis of CRS was 1.550 [95% confidence interval (95% CI) = 1.516-1.584], suggesting a moderate association between these conditions. This association was consistent across gender-specific analyses. Of the male sampled patients, the adjusted odds ratio of prior CP for patients with CRS was 1.622 (95% CI = 1.571-1.675) than controls.
This study underscores a significant association between CRS and prior CP, suggesting that periodontal health might influence or exacerbate the pathogenesis of sinusitis. The findings advocate for integrated approaches in managing patients with CRS, emphasizing the importance of periodontal health assessments as part of the clinical management of CRS.
This study aimed to explore the association of chronic rhinosinusitis (CRS) with prior chronic periodontitis (CP). We performed a case-control study using Taiwan's Longitudinal Health Insurance Database, encompassing a group of 52,733 individuals diagnosed with CRS and 158,199 matched controls without CRS. Our analysis indicated a significantly higher prevalence of prior CP among patients with CRS in comparison with controls (30.49% vs. 22.14%; p < 0.001). The adjusted odds ratio for having CP before the diagnosis of CRS was 1.550 (95% CI = 1.516-1.584), suggesting a moderate association between these conditions. This association was consistent across gender-specific analyses. Of the male sampled patients, the adjusted odds ratio of prior CP for patients with CRS was 1.622 (95% CI = 1.571-1.675) than controls. This study underscores a significant association between CRS and prior CP, suggesting that periodontal health might influence or exacerbate the pathogenesis of sinusitis. The findings advocate for integrated approaches in managing patients with CRS, emphasizing the importance of periodontal health assessments as part of the clinical management of CRS.
慢性鼻窦炎（CRS）和慢性牙周炎（CP）是常见的炎症性疾病，对健康有重大影响。先前的研究表明这两种疾病之间可能存在联系，主要通过牙源性途径，但基于人群的全面研究较少。本研究旨在探讨CRS与既往CP之间的关联。
我们使用台湾纵向健康保险数据库进行了一项病例对照研究，纳入了52733例被诊断为CRS的个体和158199例匹配的无CRS对照。该研究使用国际疾病分类代码识别患有既往CP的患者，检查他们在CRS诊断索引日期之前的患病率，并与无CRS的匹配对照进行比较。针对人口统计学和健康变量进行调整的多重逻辑回归模型评估了CRS与CP之间的关联。
我们的分析表明，与对照组相比，CRS患者中CP的患病率显著更高（30.49%对22.14%；p<0.001）。CRS诊断前患有CP的调整后优势比为1.550[95%置信区间（95%CI）=1.516 - 1.584]，表明这两种情况之间存在中度关联。这种关联在按性别进行的分析中是一致的。在抽样的男性患者中，CRS患者既往CP的调整后优势比为1.622（95%CI = 1.571 - 1.675），高于对照组。
本研究强调了CRS与既往CP之间的显著关联，表明牙周健康可能影响或加剧鼻窦炎的发病机制。研究结果主张采用综合方法管理CRS患者，强调牙周健康评估作为CRS临床管理一部分的重要性。
本研究旨在探讨慢性鼻窦炎（CRS）与既往慢性牙周炎（CP）之间的关联。我们使用台湾纵向健康保险数据库进行了一项病例对照研究，纳入了52733例被诊断为CRS的个体和158199例匹配的无CRS对照。我们的分析表明，与对照组相比，CRS患者中既往CP的患病率显著更高（30.49%对22.14%；p<0.001）。CRS诊断前患有CP的调整后优势比为1.550（95%CI = 1.516 - 1.584），表明这两种情况之间存在中度关联。这种关联在按性别进行的分析中是一致的。在抽样的男性患者中，CRS患者既往CP的调整后优势比为1.622（95%CI = 1.571 - 1.675），高于对照组。本研究强调了CRS与既往CP之间的显著关联，表明牙周健康可能影响或加剧鼻窦炎的发病机制。研究结果主张采用综合方法管理CRS患者，强调牙周健康评估作为CRS临床管理一部分的重要性。
