Baig Mirza Asfand, Fayez Feras, Rashed Sami, Shahid Ammal Bibi, Sharma Chaitanya, Suvarna Rishabh, Vastani Amisha, Serag Ahmed, Nader-Sepahi Ali, Montgomery Alexander, Malik Irfan, Grahovac Gordan, Arvin Babak, Sadek Ahmed-Ramadan
Department of Neurosurgery, Queens Hospital, Romford, London, UK.
Charing Cross Hospital, London, UK.
Eur Spine J. 2025 Apr 2. doi: 10.1007/s00586-025-08816-x.
This study aimed to evaluate the prolapse to canal ratio (PCR) and its long-term impact on outcomes in cauda equina syndrome (CES).
A 5-year retrospective cohort study was conducted across two neurosurgical centers, including adult patients diagnosed with CES due to herniated lumbar discs, treated with laminectomy and/or discectomy, with available radiological data and follow-up. PCR was calculated as the proportion of the disc prolapse cross-sectional area to the total spinal canal area. MRI scans were independently analyzed by two investigators, with random verification by a third. Patient demographics, symptoms, treatment, and follow-up data were also collected.
Among 137 patients, cohorts were divided using a PCR cut-off of 0.5. Patients with PCR > 0.5 were significantly more likely to have persistent symptoms at follow-up (OR 3.93, CI 2.25-7.34, p < 0.0001). This risk increased with higher PCR thresholds (> 0.75 and > 0.8). PCR > 0.5 also predicted a greater likelihood of requiring a full laminectomy over minimally invasive approaches (OR 2.14, 95% CI 1.3-3.6, p < 0.005). Lower PCR (< 0.5) was associated with reduced complication rates and shorter hospital stays.
PCR is a valuable predictor of persistent pain and functional deficits following CES surgery and could be used to guide patient counseling before surgical intervention.
本研究旨在评估马尾综合征(CES)中脱垂与椎管比率(PCR)及其对预后的长期影响。
在两个神经外科中心进行了一项为期5年的回顾性队列研究,纳入因腰椎间盘突出症诊断为CES的成年患者,接受椎板切除术和/或椎间盘切除术治疗,有可用的放射学数据和随访资料。PCR计算为椎间盘脱垂横截面积与整个椎管面积的比例。MRI扫描由两名研究者独立分析,第三名研究者进行随机核查。还收集了患者的人口统计学资料、症状、治疗及随访数据。
137例患者中,采用PCR临界值0.5进行分组。PCR>0.5的患者在随访时出现持续性症状的可能性显著更高(比值比3.93,可信区间2.25 - 7.34,p<0.0001)。随着PCR阈值升高(>0.75和>0.8),这种风险增加。PCR>0.5还预示相比于微创方法更有可能需要进行全椎板切除术(比值比2.14,95%可信区间1.3 - 3.6,p<0.005)。较低的PCR(<0.5)与较低的并发症发生率和较短的住院时间相关。
PCR是CES手术后持续性疼痛和功能障碍的有价值预测指标,可用于在手术干预前指导患者咨询。