原发性胆汁性胆管炎和原发性硬化性胆管炎患者的疲劳和瘙痒严重程度：两个大型队列的前瞻性分析。

Fatigue and itch severity in patients with PBC and PSC: Prospective analysis of two large cohorts.

作者信息

Kruk Beata, Raszeja-Wyszomirska Joanna, Krawczyk Marcin, Milkiewicz Piotr

机构信息

Laboratory of Metabolic Liver Diseases, Department of General, Transplant and Liver Surgery, Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland.

Liver and Internal Medicine Unit, Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.

出版信息

Eur J Clin Invest. 2025 Jul;55(7):e70041. doi: 10.1111/eci.70041. Epub 2025 Apr 3.

DOI:10.1111/eci.70041

PMID:40178005

Abstract

Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are rare liver diseases that significantly impair quality of life (QoL). In this study, we analysed two large cohorts comprising a total of 1267 patients with PBC and PSC, showing that fatigue is a frequent symptom in both conditions, particularly among females. Fatigue was associated with liver function markers (ALP/GGT in PSC) and with cirrhosis (in PBC). It was also often linked to cholestatic pruritus, further compromising QoL.

摘要

原发性胆汁性胆管炎（PBC）和原发性硬化性胆管炎（PSC）是罕见的肝脏疾病，会严重损害生活质量（QoL）。在本研究中，我们分析了两个大型队列，共纳入1267例PBC和PSC患者，结果显示疲劳是这两种疾病的常见症状，在女性中尤为常见。疲劳与肝功能指标（PSC中的碱性磷酸酶/γ-谷氨酰转肽酶）和肝硬化（PBC中）相关。它还常常与胆汁淤积性瘙痒有关，进一步损害生活质量。