异丙肾上腺素对大鼠气管体外制备物纤毛活动的影响。

The effect of isoprenaline on the ciliary activity of an in vitro preparation of rat trachea.

作者信息

Lopez-Vidriero M T, Jacobs M, Clarke S W

出版信息

Eur J Pharmacol. 1985 Jun 19;112(3):429-32. doi: 10.1016/0014-2999(85)90793-9.

Abstract

A dose dependent increase in the ciliary beat frequency of rat tracheal explants was found over a 10(-7)-10(-3) M concentration range of (+/-)-isoprenaline and was abolished by 10(-7) M propranolol. Furthermore (+)-isoprenaline, a drug which is much less potent in its action on beta-adrenoceptors than its (-)-isomer, failed to cause a stimulation. We conclude that the acceleration in the intrinsic ciliary beat frequency by (-)-isoprenaline, although occurring at a relatively high concentration compared with the action of the drug on other tissues, is mediated by beta-adrenoceptors.

摘要

在（±）-异丙肾上腺素浓度范围为10⁻⁷ - 10⁻³ M时，发现大鼠气管外植体的纤毛摆动频率呈剂量依赖性增加，且10⁻⁷ M普萘洛尔可消除这种增加。此外，（+）-异丙肾上腺素对β-肾上腺素受体的作用远不如其（-）-异构体有效，未能引起刺激。我们得出结论，（-）-异丙肾上腺素使内在纤毛摆动频率加速，尽管与该药物对其他组织的作用相比发生在相对较高的浓度，但它是由β-肾上腺素受体介导的。