慢性病毒感染与阿尔茨海默病淀粉样变性：一种罕见的关联。
Chronic Viral Infections and Al Amyloidosis: An Uncommon Association.
作者信息
Palladini Alberto, Cusumano Gabriele, Martellucci Ottavio, Gigante Antonietta, D'Ettorre Gabriella, Petrucci Maria Teresa, Muscaritoli Maurizio, Palladino Mariangela
机构信息
Department of Translational and Precision Medicine Sapienza University of Rome Rome Italy.
Department of Public Health and Infectious Disease Sapienza University of Rome Rome Italy.
出版信息
Clin Case Rep. 2025 Apr 2;13(4):e9616. doi: 10.1002/ccr3.9616. eCollection 2025 Apr.
AL-amyloidosis is caused by deposition of pathological insoluble proteins in organs and tissues. HIV infection is a multi-system disorder causing chronic inflammation. We report a case of AL-amyloidosis associated with HIV suggesting that HIV-associated immune dysregulation might be critical for pathogenesis of plasma cells dyscrasias and then AL amyloidosis.
轻链型淀粉样变性是由病理性不溶性蛋白质在器官和组织中的沉积引起的。HIV感染是一种导致慢性炎症的多系统疾病。我们报告了一例与HIV相关的轻链型淀粉样变性病例，提示HIV相关的免疫失调可能对浆细胞异常增殖症及随后的轻链型淀粉样变性的发病机制至关重要。
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