Simeonov Louise, Das Ravi
Clinical Psychopharmacology Unit, Research Department of Clinical, Educational, and Health Psychology, University College London, London, United Kingdom.
Front Behav Neurosci. 2025 Mar 13;19:1555081. doi: 10.3389/fnbeh.2025.1555081. eCollection 2025.
A fundamental question in cognitive neuroscience is how multi-sensory elements are bound into a unified memory trace. The formation of memories is thought to be reliant on precisely timed neural activity. Theta frequency neural oscillations have been proposed to orchestrate the timing of different sensory cortices. Here, we attempt to replicate findings that flickering stimuli presented in synchronous theta frequency will lead to enhanced recall. Additionally, we investigate whether theta frequency sensory flicker can improve encoding of emotional associative memories. The current study failed to replicate previous findings demonstrating improved recall for stimuli synchronously modulated at theta frequency in a multi-sensory associative learning task. We discuss possible explanations for the discrepancy between current and previous findings.
认知神经科学中的一个基本问题是多感官元素如何被整合到一个统一的记忆痕迹中。记忆的形成被认为依赖于精确计时的神经活动。有人提出,θ波频率的神经振荡可协调不同感觉皮层的时间。在此,我们试图重复这样的发现:以同步θ波频率呈现的闪烁刺激会提高回忆效果。此外,我们还研究了θ波频率的感觉闪烁是否能改善情绪关联记忆的编码。在一项多感官联想学习任务中,当前的研究未能重复先前的发现,即对于以θ波频率同步调制的刺激,回忆效果会得到改善。我们讨论了当前与先前研究结果之间差异的可能解释。