Vandghanooni Somayeh, Jaymand Mehdi, Eskandani Morteza
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Drug Dev Ind Pharm. 2025 Jun;51(6):523-533. doi: 10.1080/03639045.2025.2489594. Epub 2025 Apr 18.
Nanomedicine is the application of nanotechnology to medicine and, therefore, a potentially transformative approach to healthcare. This new and interdisciplinary field has three main applications in diagnostics, controlled/targeted drug delivery, and regenerative medicine. Nanomedicine has great potential to change human health by advancing diagnosis, prevention and treatment for a wide variety of diseases, including cancer, cardiovascular conditions, and neurological disorders. Despite the overwhelming potential, there are some issues impeding the complete integration of nanomedicines into healthcare systems.
This policy brief addresses such critical issues to inform and guide decision-making on effectively deploying nanomedicine to improve patient outcomes and advance important public health initiatives. In addition, some prospects were also presented for the future. It discusses the current barriers to their wide application, particularly regarding regulatory hurdles and the production of robust clinical evidence.
These brand-new nanosystems have some serious drawbacks in regard to safety, efficacy, and regulatory compliance, not to mention public acceptance. Nanomaterials can be so complex that their manufacturing processes become complex, which may potentially bring into question long-term effects on human health and the environment.
This policy brief identifies key considerations for policymakers and stakeholders, highlighting the requirement for integration among researchers, clinicians, and regulatory bodies. To facilitate the safe and successful integration of nanomedicines into patient care, continued collaboration are imperative. Priority in the future should be given to developing comprehensive regulatory frameworks, raising public awareness, and promoting interdisciplinary research to resolve existing challenges and unlock the potential of nanomedicines in the healthcare sector.
纳米医学是纳米技术在医学领域的应用,因此是一种具有潜在变革性的医疗保健方法。这个新兴的跨学科领域在诊断、可控/靶向药物递送和再生医学方面有三个主要应用。纳米医学通过推进对包括癌症、心血管疾病和神经紊乱在内的多种疾病的诊断、预防和治疗,具有改变人类健康的巨大潜力。尽管潜力巨大,但仍有一些问题阻碍纳米药物完全融入医疗保健系统。
本政策简报探讨了此类关键问题,为有效部署纳米医学以改善患者治疗效果和推进重要的公共卫生举措提供信息并指导决策。此外,还展望了未来的一些前景。它讨论了纳米药物广泛应用目前面临的障碍,特别是监管方面的障碍以及有力临床证据的产生。
这些全新的纳米系统在安全性、有效性和监管合规性方面存在一些严重缺陷,更不用说公众接受度了。纳米材料可能非常复杂,以至于其制造过程也变得复杂,这可能会对人类健康和环境的长期影响带来疑问。
本政策简报确定了政策制定者和利益相关者的关键考虑因素,强调了研究人员、临床医生和监管机构之间整合的必要性。为了促进纳米药物安全、成功地融入患者护理,持续的合作势在必行。未来应优先制定全面的监管框架、提高公众意识并促进跨学科研究,以解决现有挑战并释放纳米药物在医疗保健领域的潜力。