一种阳离子锝四胺配合物的化学和生物学性质。
Chemical and biological properties of a cationic Tc-tetraamine complex.
作者信息
Bläuenstein P, Pfeiffer G, Schubiger P A, Anderegg G, Zollinger K, May K, Proso Z, Ianovici E, Lerch P
出版信息
Int J Appl Radiat Isot. 1985 Apr;36(4):315-7. doi: 10.1016/0020-708x(85)90093-6.
The complex of 99Tc with the ligand 1,4,8,11-tetraazaundecane (2,3,2-tet) was prepared and was compared with the similar 99Tc complexes with ethylenediamine and 1,4,8,11-tetraazacyclotetradecane. The results are all consistent with the formula [TcO2(2,3,2-tet)]+. The biological behavior was tested with 99mTc in Wistar rats. A fast clearance via the kidneys was found, and no accumulation in any other organ was observed.
制备了99Tc与配体1,4,8,11-四氮杂十一烷（2,3,2-四）的配合物，并将其与99Tc与乙二胺和1,4,8,11-四氮杂环十四烷的类似配合物进行了比较。结果均与化学式[TcO2(2,3,2-四)]+一致。用99mTc在Wistar大鼠中测试了其生物学行为。发现通过肾脏快速清除，未观察到在任何其他器官中的积累。
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