Haber R M, Ramsay C A, Boxall L B
Int J Dermatol. 1985 Jun;24(5):324-8. doi: 10.1111/j.1365-4362.1985.tb05796.x.
Nineteen patients with a variety of types of epidermolysis bullosa were initially assessed in an open study of a treatment regime for the genetic type of epidermolysis bullosa. Nine of the ten patients admitted to the hospital for treatment showed definite objective improvement with decreased number of blisters and increased rate of healing of blisters. The mean percentage decrease in blister numbers from the time of admission until discharge from hospital was 76%. Sixteen patients were followed as outpatients for 5-11 months. Two patients continued to show objective improvement, while eight reported more rapid healing of their blisters. Six patients failed to improve. This treatment has a beneficial effect in inpatients with epidermolysis bullosa. The improvement may be due to the intense topical treatment rather than to a specific item of the therapy. In the long term, this treatment has little effect on the formation of new blisters, but an accelerated healing of blisters is reported by 50% of the patients.
在一项针对遗传性大疱性表皮松解症治疗方案的开放性研究中，最初对19例各种类型大疱性表皮松解症患者进行了评估。入院接受治疗的10例患者中有9例显示出明确的客观改善，水疱数量减少，水疱愈合速度加快。从入院到出院水疱数量平均减少的百分比为76%。16例患者作为门诊患者随访了5至11个月。2例患者持续显示出客观改善，而8例报告水疱愈合更快。6例患者未见改善。这种治疗方法对大疱性表皮松解症住院患者有有益作用。改善可能归因于强化的局部治疗，而非治疗中的某一特定项目。从长期来看，这种治疗方法对新水疱的形成影响不大，但50%的患者报告水疱愈合加快。
