Sack J, Kletter G, Amado O, Akstein E
Isr J Med Sci. 1985 Jun;21(6):485-9.
The neonatal hypothyroidism (NH) screening program in Israel was initiated in May 1978, and by the end of April 1984, 538,565 infants had been screened. One hundred sixty-six newborns were found to have NH; 7 of these exhibited only transient hypothyroidism. During the screening period the average age for initiation of treatment decreased from 6 to 4.8 weeks. A thyroid scan was performed on 51 of the neonates with NH; 41% had agenesis of the thyroid, 24% ectopic thyroid tissue, 29% dyshormonogenesis, and 6% secondary or tertiary hypothyroidism. This high incidence of dyshormonogenesis in Israel is probably due to a high rate of consanguinity among the Arab population and also within some of the Jewish ethnic groups. No blood sample was received from four infants with NH, and one infant with NH was not notified. This study indicates that a neonatal screening program can effectively detect infants with NH, resulting in earlier treatment.
以色列的新生儿甲状腺功能减退症（NH）筛查项目始于1978年5月，到1984年4月底，已有538,565名婴儿接受了筛查。发现166名新生儿患有NH；其中7名仅表现为暂时性甲状腺功能减退。在筛查期间，开始治疗的平均年龄从6周降至4.8周。对51名患有NH的新生儿进行了甲状腺扫描；41%甲状腺缺如，24%有异位甲状腺组织，29%激素合成障碍，6%为继发性或三发性甲状腺功能减退。以色列激素合成障碍的高发病率可能是由于阿拉伯人群以及一些犹太族群中近亲结婚率较高。有4名患有NH的婴儿未收到血样，1名患有NH的婴儿未得到通知。这项研究表明，新生儿筛查项目能够有效检测出患有NH的婴儿，从而实现更早治疗。
