Feng Kunyang, Wang Hanting, Zhou Song, Zhang Wei, Gong Chonghai, He Yuxin, Wang Yusen, Dai Wenchong, Li Jianbo, Zhang Zhengwei, Li Siqiao
School of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Chongqing Key Laboratory of Forensic Medicine, Chongqing Medical University, Chongqing, 400016, China.
Adv Sci (Weinh). 2025 Jul;12(25):e2502354. doi: 10.1002/advs.202502354. Epub 2025 Apr 7.
High-entropy alloys (HEAs) have garnered extensive attention owing to their broad compositional tunability and high catalytic activity. However, precisely modulating the enzyme-like activity of HEAs and enhancing their biocompatibility for biological applications remain severely challenging. Herein, PtRuFeCoNi HEA nanowires (NWs) are synthesized by adjusting the metal composition and surface-engineered with polydopamine (PDA) to form HEA NWs@PDA nanozymes (HEzymes@PDA) with superior catalytic activity and photothermal properties. Density functional theory calculations and the Sabatier principle reveal that self-polymerized PDA surface engineering moderately lowers the d-band center of the HEAs, optimizes the surface charge distribution, and enhances the adsorption-desorption efficiency of the substrates. As a proof-of-concept, the HEzymes@PDA are synergistically integrated with hydrogels for biosensing analysis. This study presents an innovative paradigm for designing highly active HEA nanozymes via surface engineering and demonstrates their immense potential in catalytic sensing applications.
高熵合金（HEAs）因其广泛的成分可调性和高催化活性而受到广泛关注。然而，精确调节高熵合金的类酶活性并提高其在生物应用中的生物相容性仍然极具挑战性。在此，通过调整金属成分合成了PtRuFeCoNi高熵合金纳米线（NWs），并用聚多巴胺（PDA）进行表面工程处理，以形成具有优异催化活性和光热性能的高熵合金纳米线@PDA纳米酶（纳米酶@PDA）。密度泛函理论计算和萨巴蒂尔原理表明，自聚合的PDA表面工程适度降低了高熵合金的d带中心，优化了表面电荷分布，并提高了底物的吸附-解吸效率。作为概念验证，纳米酶@PDA与水凝胶协同集成用于生物传感分析。本研究提出了一种通过表面工程设计高活性高熵合金纳米酶的创新范例，并展示了它们在催化传感应用中的巨大潜力。
