De Geronimo Daniele, Parravano Mariacristina, Sacconi Riccardo, Costanzo Eliana, Varano Monica, Querques Giuseppe
IRCCS - Fondazione Bietti, Rome, Italy.
Department of Health Sciences, UniCamillus-Saint Camillus International Medical University, Rome, Italy.
Ophthalmologica. 2025;248(3):168-174. doi: 10.1159/000544958. Epub 2025 Apr 8.
To analyze and correlate the topographic distribution of atrophic areas at the posterior pole and peripheral retina in subjects with geographic atrophy (GA) using ultra-widefield fundus autofluorescence (FAF) imaging.
This multicenter observational study included 15 patients (9 males, 19 eyes) with coexisting GA and peripheral atrophy. All eyes were imaged with Ultra-widefield Optos California (Optos, PLC, Dunfermline, Scotland) to acquire ultra-widefield (200°) color and FAF images centered on the fovea, superior, inferior, nasal, and temporal sectors. The extent of GA in the central FAF image and the peripheral atrophic areas in the peripheral FAF images were measured by manually defining the boundaries of the atrophic regions using the "ROI free" function integrated into the device software. The values obtained were then analyzed and correlated.
The mean ± standard deviation (SD) GA size was 13.9 ± 15.0 mm2 (range: 1.8-71.3 mm2) and the total peripheral atrophy was 51.0 ± 68.3 mm2 (range: 1.4-292.1 mm2). The topographic analysis showed that the mean ± SD of superior peripheral atrophy was 9.0 ± 20.6 mm2, temporal atrophy was 30.5 ± 55.9 mm2, inferior atrophy was 9.3 ± 16.3 mm2, and nasal atrophy was 1.8 ± 3.9 mm2. GA size was significantly correlated with total peripheral atrophy (Rho = 0.463, p = 0.046) and temporal peripheral atrophy (Rho = 0.474, p = 0.040), whereas no correlations were found with peripheral atrophy in the remaining sectors.
Ultra-widefield autofluorescence is a valuable technique for visualizing and assessing the extent of macular and peripheral atrophy. Macular atrophy correlates significantly with total and temporal peripheral atrophy but demonstrates no significant correlation with atrophy in the remaining sectors.
使用超广角眼底自发荧光（FAF）成像分析并关联地图样萎缩（GA）患者后极部和周边视网膜萎缩区域的地形分布。
这项多中心观察性研究纳入了15例同时患有GA和周边萎缩的患者（9例男性，19只眼）。所有眼睛均使用超广角Optos California（Optos公司，PLC，邓弗姆林，苏格兰）进行成像，以获取以黄斑为中心的超广角（200°）彩色和FAF图像，包括上方、下方、鼻侧和颞侧区域。通过使用设备软件中集成的“无ROI”功能手动定义萎缩区域的边界，测量中央FAF图像中GA的范围以及周边FAF图像中周边萎缩区域的范围。然后对获得的值进行分析和关联。
GA的平均±标准差（SD）大小为13.9±15.0 mm²（范围：1.8 - 71.3 mm²），周边总萎缩面积为51.0±68.3 mm²（范围：1.4 - 292.1 mm²）。地形分析显示，上方周边萎缩的平均±SD为9.0±20.6 mm²，颞侧萎缩为30.5±55.9 mm²，下方萎缩为9.3±16.3 mm²，鼻侧萎缩为1.8±3.9 mm²。GA大小与周边总萎缩（Rho = 0.463，p = 0.046）和颞侧周边萎缩（Rho = 0.474，p = 0.040）显著相关，而与其余区域的周边萎缩无相关性。
超广角自发荧光是一种用于可视化和评估黄斑及周边萎缩范围的有价值技术。黄斑萎缩与周边总萎缩和颞侧周边萎缩显著相关，但与其余区域的萎缩无显著相关性。
