Mingchay Pichanon, Uthaithammarat Lita, Reinprayoon Usanee, Nilaratanakul Voraphoj
Division of Infectious Diseases, Department of Medicine, Chulalongkorn University, Bangkok, Bangkok, Thailand.
Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Bangkok, Thailand.
BMJ Case Rep. 2025 Apr 8;18(4):e260340. doi: 10.1136/bcr-2024-260340.
A well-managed hypertensive and dyslipidaemic female in her 60s presented with a 4 month history of progressive visual decline, ocular irritation and localised erythema in her right eye. These ocular symptoms were associated with repeated exposure to environmental water sources. Clinical evaluation revealed marked conjunctival injection, corneal oedema, diffuse stromal haze and a dense infiltrate with a 6×6 mm epithelial defect at the central cornea. A penetrating keratoplasty revealed acid-fast bacilli in the corneal pathology, confirmed as via the line probe assay. Mycobacterial growth was absent in culture.A comprehensive treatment regimen, including systemic amikacin, levofloxacin, rifampicin, azithromycin and topical antituberculous therapy, resulted in significant clinical improvement. This case highlights as an infrequent cause of non-tuberculous mycobacterial keratitis. Recurrent eye contact with contaminated water was shown as a notable risk factor in the absence of prior corneal interventions.
一名60多岁的高血压和血脂异常控制良好的女性,右眼出现了4个月的渐进性视力下降、眼部刺激和局部红斑病史。这些眼部症状与反复接触环境水源有关。临床评估显示结膜明显充血、角膜水肿、弥漫性基质混浊,中央角膜有一个6×6毫米的上皮缺损和致密浸润。穿透性角膜移植术在角膜病理中发现抗酸杆菌,通过线性探针检测确诊为 。培养中未发现分枝杆菌生长。包括全身使用阿米卡星、左氧氟沙星、利福平、阿奇霉素和局部抗结核治疗在内的综合治疗方案使临床症状显著改善。该病例突出了 作为非结核分枝杆菌性角膜炎罕见病因的情况。在没有先前角膜干预的情况下,反复眼部接触受污染的水被证明是一个显著的危险因素。