Kim Gahee, Go Unyeong, Park Gyuri, Kim Yujin, Jeong Hyeran, Park Ahyoung, Park Young-Joon
Director for Tuberculosis Policy, Department of Infectious Disease Policy, Korea Disease Control and Prevention Agency, 187, Osongsaengmyeong 2-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, 28159, Republic of Korea.
Medical director of Infectious Disease Research Center, Department of Laboratory Medicine, Green Cross Laboratories, 107, Ihyeonro 30 beon-gil, Giheng-gu, Yongin-si, 16924 Gyeonggi-do, Republic of Korea.
IJID Reg. 2025 Mar 19;14(Suppl 2):100600. doi: 10.1016/j.ijregi.2025.100600. eCollection 2025 Mar.
This study aimed to outline the processes and identify key success factors of the 2018 latent tuberculosis (TB) infection (LTBI) screening program for high school teachers in Korea, conducted as part of a series of large-scale screening initiatives.
In 2018, we screened 4692 school teachers from 121 schools, and the data were recorded in the "TB-net" of the Korea Disease Control and Prevention Agency (KDCA). We analyzed the characteristics of the examinees by sex and age, in addition to the LTBI rate, and the initiation and completion rate of TB preventive treatment (TPT).
Of the 4692 teachers screened, the LTBI prevalence was 20.0%, with rates increasing with age. Among the 938 individuals diagnosed with LTBI, 31.0% initiated TPT. Of these, 226 individuals completed treatment, yielding a treatment completion rate of 77.7%. The preferred treatment regimens were 3 months isoniazid + rifampin (3HR) (83.8%), 4 months rifampin (4R) (13.7%), and 9 months isoniazid (2.4%). Completion rates were highest among those on the 4R regimen (87.5%), followed by the 3HR regimen (77.0%).
The success of this program can be attributed to a comprehensive and well-structured process that included prior education and informed consent, screenings and treatments conducted in designated clinics and hospitals, and robust side-effect management for TPT.
本研究旨在概述韩国针对高中教师开展的2018年潜伏性结核感染（LTBI）筛查项目的流程，并确定其关键成功因素，该项目是一系列大规模筛查举措的一部分。
2018年，我们对来自121所学校的4692名学校教师进行了筛查，并将数据记录在韩国疾病控制与预防机构（KDCA）的“结核病网络”中。除LTBI率以及结核预防性治疗（TPT）的启动率和完成率外，我们还按性别和年龄分析了受检者的特征。
在接受筛查的4692名教师中，LTBI患病率为20.0%，患病率随年龄增长而上升。在938名被诊断为LTBI的个体中，31.0%启动了TPT。其中，226人完成了治疗，治疗完成率为77.7%。首选的治疗方案为3个月异烟肼+利福平（3HR）（83.8%）、4个月利福平（4R）（13.7%）和9个月异烟肼（2.4%）。4R方案的完成率最高（87.5%），其次是3HR方案（77.0%）。
该项目的成功可归因于一个全面且结构良好的流程，包括事先教育和知情同意、在指定诊所和医院进行筛查和治疗，以及对TPT进行有力的副作用管理。
