Titisari Nurina, Ahmad Hafandi, Samsulrizal Nurdiana, Fauzi Ahmad, Abdul Razak Intan Shameha
Department of Veterinary Physiology, Faculty of Veterinary Medicine, Universitas Brawijaya, Malang, Indonesia.
Department of Veterinary Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang,Malaysia.
Open Vet J. 2025 Feb;15(2):594-600. doi: 10.5455/OVJ.2025.v15.i2.8. Epub 2025 Feb 28.
Streptozotocin (STZ) is a widely used chemical agent in biomedical research. It is primarily known for its ability to induce high blood glucose levels in animal models by selectively destroying pancreatic beta cells. Nonetheless, many studies have also used STZ to generate animal models of diabetic complications, such as Alzheimer's disease (AD) animal models. STZ induction promotes hyperglycemia, which activates numerous mechanism pathways that result in the production of pathogenic AD characteristics, including beta-amyloid accumulation and neurofibrillary tangles. Numerous theories exist to elucidate the mechanisms underlying diabetes and AD; however, studies on the potential of an animal model of STZ-induced AD remain limited. Thus, this review summarizes the pathogenesis associated with STZ exposure, particularly in AD animal model studies related to diabetes. More specifically, this study will discuss the relationship between increased blood glucose levels after STZ injection and the process of beta-amyloid formation and insulin dysfunction in the brain.
链脲佐菌素（STZ）是生物医学研究中广泛使用的化学试剂。它主要以能够通过选择性破坏胰腺β细胞在动物模型中诱导高血糖水平而闻名。尽管如此，许多研究也使用STZ来建立糖尿病并发症的动物模型，如阿尔茨海默病（AD）动物模型。STZ诱导会促进高血糖，这会激活众多机制途径，导致产生致病性AD特征，包括β-淀粉样蛋白积累和神经纤维缠结。存在许多理论来阐明糖尿病和AD的潜在机制；然而，关于STZ诱导的AD动物模型潜力的研究仍然有限。因此，本综述总结了与STZ暴露相关的发病机制，特别是在与糖尿病相关的AD动物模型研究中。更具体地说，本研究将讨论STZ注射后血糖水平升高与大脑中β-淀粉样蛋白形成过程和胰岛素功能障碍之间的关系。
