免疫纠正对下颌骨骨折修复性骨生成的影响：一项组织形态计量学研究。
The Effect of Immunocorrection on Reparative Osteogenesis in Mandibular Fracture: A Histomorphometric Study.
作者信息
Mammadov Jahid, Davudov Mahammad, Aliyev Toghrul, Isgandarova Surayya
机构信息
Department of Oral and Maxillofacial Surgery, Azerbaijan Medical University, Baku, Azerbaijan.
出版信息
J Craniofac Surg. 2025;36(5):e568-e571. doi: 10.1097/SCS.0000000000011404. Epub 2025 Apr 9.
BACKGROUND
Fracture consolidation is a fundamental factor in understanding the biological process of bone healing in human. The objective of this study was to evaluate the effects of immunocorrection after trauma surgery on bone healing process in mandibular fracture in rabbits.
METHODS
This study carried out using 24 rabbits. In all rabbits, the mandibular fracture model and osteogenesis carried out on the fracture site by titanium miniplates and screws. Blood analysis performed before and during the treatment. The animals slaughtered and fractured site removed for morphologic studies at baseline and follow-up assessments.
RESULTS
After surgical trauma in all animals, immunologic indicators of blood including circulating immunocomplex, complements, and lysosomes have been reduced.
CONCLUSION
General immunity and histomorphometric evaluation of the present study showed posttraumatic immunodeficiency could affects bone healing.
背景
骨折愈合是理解人类骨愈合生物学过程的一个基本因素。本研究的目的是评估创伤手术后免疫纠正对兔下颌骨骨折愈合过程的影响。
方法
本研究使用24只兔子进行。对所有兔子制作下颌骨骨折模型，并通过微型钛板和螺钉在骨折部位进行骨生成。在治疗前和治疗期间进行血液分析。在基线和随访评估时宰杀动物并取出骨折部位进行形态学研究。
结果
所有动物在手术创伤后，血液中的免疫指标，包括循环免疫复合物、补体和溶酶体均有所降低。
结论
本研究的总体免疫和组织形态计量学评估表明，创伤后免疫缺陷可能影响骨愈合。
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