Chen Li-Ching, Chang Han-Sheng, Ho Yuan-Soon
Department of Biological Science & Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.
Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan.
J Food Drug Anal. 2025 Mar 31;33(1):1-12. doi: 10.38212/2224-6614.3539.
Apples, a ubiquitous and beloved fruit, harbor a treasure trove of bioactive compounds, with apple polyphenols (APs) taking center stage. This review delves into the latest scientific advancements illuminating the anti-cancer and anti-aging properties of APs. We dissect the intricate mechanisms by which APs combat cancer initiation, progression, and metastasis, highlighting their prowess in inducing apoptosis, inhibiting angiogenesis, and modulating cell signaling pathways. Furthermore, we explore the multifaceted ways APs combat aging, including their potent antioxidant and anti-inflammatory actions, DNA protective effects, and ability to modulate cellular processes like autophagy and metabolism. This comprehensive review underscores the therapeutic promise of APs in promoting healthy aging and combating age-related diseases like cancer.
苹果，一种随处可见且备受喜爱的水果，蕴藏着丰富的生物活性化合物，其中苹果多酚（APs）占据核心地位。这篇综述深入探讨了揭示苹果多酚抗癌和抗衰老特性的最新科学进展。我们剖析了苹果多酚对抗癌症起始、进展和转移的复杂机制，强调了它们在诱导细胞凋亡、抑制血管生成以及调节细胞信号通路方面的卓越能力。此外，我们还探索了苹果多酚对抗衰老的多方面方式，包括其强大的抗氧化和抗炎作用、对DNA的保护作用，以及调节自噬和代谢等细胞过程的能力。这篇全面的综述强调了苹果多酚在促进健康衰老和对抗癌症等与年龄相关疾病方面的治疗前景。
