低出生体重儿血浆游离氨基酸的研究，以及经口喂哺牛奶与全胃肠外营养的比较。

A study of the plasma free amino acids in infants of low birth weight, with a comparison of oral feeding with milk and total parenteral nutrition.

作者信息

Higgs S C, Malan A F, de V Heese H

出版信息

S Afr Med J. 1977 Jan 1;51(1):5-9.

PMID:402034

Abstract

The plasma amino acid concentrations soon after birth, at 10 days and 1 month, were estimated in 25 infants of low birth weight (less than 1 500 g). Ten of these infants were fed with amino acids as casein hydrolysate, through the umbilical artery for the first 10 days. The normal range of plasma amino acid values for infants of low birth weight shows a wider range of concentrations than that of term infants. During total parenteral nutrition (TPN) the plasma amino acid values were generally elevated above those obtained in infants receiving conventional feeding with a "humanised" milk formula. In particular, the concentrations of aspartic acid, phenylalanine, cystine, leucine, isoleucine and glutamic acid were significantly higher. With the cessation of TPN, these levels returned to normal, so that no significant difference could be detected between the 2 groups after 1 month. The suitability of current amino acid solutions for paediatric use is discussed.

摘要

对25名低出生体重（小于1500克）婴儿出生后不久、出生10天及1个月时的血浆氨基酸浓度进行了评估。其中10名婴儿在出生后的头10天通过脐动脉给予氨基酸酪蛋白水解物。低出生体重婴儿血浆氨基酸值的正常范围显示其浓度范围比足月儿的更宽。在全胃肠外营养（TPN）期间，血浆氨基酸值通常高于接受“人乳化”牛奶配方常规喂养的婴儿。特别是，天冬氨酸、苯丙氨酸、胱氨酸、亮氨酸、异亮氨酸和谷氨酸的浓度显著更高。随着TPN的停止，这些水平恢复正常，因此1个月后两组之间未检测到显著差异。讨论了目前氨基酸溶液用于儿科的适用性。