Kim Choon Mee, Seo Jun-Won, Kim Da Young, Yun Na Ra, Lee Beomgi, Lee You Mi, Muhammad Munawir, Kim Dong-Min
Premedical Science, College of Medicine, Chosun University, Gwangju, South Korea.
Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea.
Malar J. 2025 Apr 10;24(1):117. doi: 10.1186/s12936-025-05329-2.
Asymptomatic malaria poses a significant challenge to malaria eradication efforts and delays global elimination strategies. Mixed infections are also a major concern, as they frequently relapse, increase the risk of severe malaria, require more accurate diagnosis for appropriate treatment, and contribute to the development of drug resistance.
A 25-year-old soldier was diagnosed with malaria following deployment in South Sudan. A comprehensive survey identified an asymptomatic Plasmodium falciparum infection, confirmed by peripheral blood smear and polymerase chain reaction (PCR). Despite being discharged after treatment, the patient developed fever and other symptoms one month later. Subsequent laboratory tests confirmed Plasmodium ovale infection based on peripheral blood smears and PCR.
This case underscores the importance of molecular detection for surveillance and vigilant follow-up in malaria management, particularly among patients with a history of deployment in endemic regions. The detection of P. ovale after treatment for P. falciparum highlights the need for increased awareness and testing for mixed infections to ensure effective malaria control strategies.
无症状疟疾对疟疾根除工作构成重大挑战，并延缓全球消除战略。混合感染也是一个主要问题，因为它们经常复发，增加重症疟疾风险，需要更准确的诊断以进行适当治疗，并助长耐药性的发展。
一名25岁士兵在南苏丹部署后被诊断出患有疟疾。全面调查发现了无症状的恶性疟原虫感染，经外周血涂片和聚合酶链反应（PCR）确诊。尽管治疗后出院，但患者一个月后出现发热和其他症状。随后的实验室检查根据外周血涂片和PCR确诊为卵形疟原虫感染。
该病例强调了分子检测在疟疾监测和管理中进行密切随访的重要性，特别是在有流行地区部署史的患者中。恶性疟原虫治疗后检测到卵形疟原虫凸显了提高对混合感染的认识和检测的必要性，以确保有效的疟疾控制策略。
