Mitsuboshi Satoru, Imai Shungo, Tsuchiya Masami, Kizaki Hayato, Hori Satoko
Department of Pharmacy, Kaetsu Hospital, Niigata, Japan.
Division of Drug Informatics, Keio University Faculty of Pharmacy, Tokyo, Japan.
Pharmacoepidemiol Drug Saf. 2025 Apr;34(4):e70146. doi: 10.1002/pds.70146.
To evaluate the accuracy of diagnostic coding for acute kidney injury (AKI) in Japan.
The data analyzed were obtained from the JMDC hospital-based administrative claims database from cases registered between April 2014 and August 2022. Only patients who underwent serum creatinine measurements two or more times with intervals of 7 days or less were eligible for inclusion. AKIs were identified by International Classification of Diseases 10th Revision (ICD-10) codes N14 and N17. These were assessed according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria.
A total of 467 019 patients (median age, 74 [range, 20-99] years; male, 50.9%) were eligible for inclusion. Among these patients, 1849 (0.4%) were assigned ICD-10 codes for AKI. Among these 1849 patients, the code was assigned within 7 days of the occurrence of AKI (as defined by the KDIGO criteria) in 212 patients, within 14 days in 294 patients, and within 30 days in 386 patients. The positive predictive values and 95% confidence intervals of the ICD-10 code for AKI at these timepoints were as follows: within 7 days, 11.5% (10.1%-13.0%); within 14 days, 15.9% (14.3%-17.6%); and within 30 days, 20.9% (19.1%-22.8%).
The ICD-10 codes for AKI showed poor positive predictive values for AKI as defined by the KDIGO criteria, suggesting that it may be difficult to identify AKI using ICD-10 codes alone in the Japanese context.
评估日本急性肾损伤(AKI)诊断编码的准确性。
分析的数据来自JMDC基于医院的行政索赔数据库,数据来源于2014年4月至2022年8月登记的病例。仅纳入血清肌酐测量次数达两次或以上且间隔时间在7天及以内的患者。通过国际疾病分类第10版(ICD-10)编码N14和N17识别AKI。根据改善全球肾脏病预后(KDIGO)标准对这些编码进行评估。
共有467019例患者(中位年龄74岁[范围20 - 99岁];男性占50.9%)符合纳入标准。在这些患者中,1849例(0.4%)被分配了AKI的ICD-10编码。在这1849例患者中,根据KDIGO标准定义,212例患者在AKI发生后7天内被分配编码,294例患者在14天内被分配编码,386例患者在30天内被分配编码。这些时间点AKI的ICD-10编码的阳性预测值及95%置信区间如下:7天内,11.5%(10.1% - 13.0%);14天内,15.9%(14.3% - 17.6%);30天内,20.9%(19.1% - 22.8%)。
KDIGO标准定义的AKI的ICD-10编码显示出较差的阳性预测值,这表明在日本的情况下,仅使用ICD-10编码可能难以识别AKI。